Catalytic Asymmetric Hydrogenation of Dehydroamino Acid Esters with Biscarbamate Protection and Its Application to the Synthesis of xCT Inhibitors

被引：5

作者：

Yasuno, Yoko ^{[1
]}

Mizutani, Iho ^{[1
]}

Sueuchi, Yuki ^{[1
]}

Wakabayashi, Yuuka ^{[1
]}

Yasuo, Nozomi ^{[1
]}

Shimamoto, Keiko ^{[2
]}

Shinada, Tetsuro ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Sci, Sumiyoshi Ku, Osaka 5588585, Japan

[2] Suntory Fdn Life Sci, Bioorgan Res Inst, 8-1-1 Seikadai,Seika Cho, Kyoto 6190284, Japan

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2019年 / 25卷 / 20期

关键词：

asymmetric catalysis; cystine-glutamate exchanger; dehydroamino acids; diaminosuberic acids; hydrogenation; orthogonal protection; ANTIPORTER SYSTEM X(C)(-); ALPHA-AMINO ACIDS; STEREOSELECTIVE-SYNTHESIS; DIAMINOSUBERIC ACID; EFFICIENT SYNTHESIS; ONE-POT; CYSTINE/GLUTAMATE ANTIPORTER; 2,7-DIAMINOSUBERIC ACID; DERIVATIVES; TRANSPORT;

D O I：

10.1002/chem.201900289

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catalytic asymmetric hydrogenation of dehydroamino acid esters with biscarbamate protection was examined for the first time to prepare optically active amino acids. The new method was successfully applied to the synthesis of new cystine-glutamate exchanger inhibitors.

引用

页码：5145 / 5148

页数：4

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