Validation of a method for sedatives and β-blockers determination in swine, bovine and equine kidney using liquid chromatography coupled with tandem mass spectrometry

被引：10
作者：
de Oliveira, Lenise Guimaraes [1 ]
Barreto, Fabiano [2 ]
Hoff, Rodrigo [2 ]
Rubensam, Gabriel [2 ]
Scherer Kurz, Marcia Helena [1 ]
Galle, Gabriela [1 ]
Gocnalves, Fabio Ferreira [1 ]
机构：
[1] Univ Fed Rio Grande FURG, Escola Quim & Alimentos, Rua Barao da Cai 125, Santo Antonio Da Patrulh, Brazil
[2] Minist Agr Pecuaria & Abastecimento, Lab Nacl Agr LANAGRO RS, Porto Alegre, RS, Brazil
来源：
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT | 2017年 / 34卷 / 01期
关键词：
beta-blockers; sedatives; LC-MS/MS; animal tissues; dispersive solid phase extraction; RESIDUES;
D O I：
10.1080/19440049.2016.1252468
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A method for the determination of five sedatives and 14 beta-blocker residues in swine, bovine and equine kidney was validated. Samples were extracted with acetonitrile and purified using dispersive solid phase extraction (d-SPE) with Celite 545 with subsequent analysis by LC-MS/MS. A simplified protocol was applied to validate the method scope extension to include new matrices. Parameters such as recovery, trueness, linearity (r(2)), relative standard deviation (RSD), decision limit (CC alpha) and method capability (CC beta) were measured for the bovine and equine kidney matrices. The method was applied to the analysis of more than 300 real samples and is currently included in the Brazilian National Residue Control Plan.
引用
收藏
页码：32 / 39
页数：8
相关论文
共 20 条
[11]   Scope extension validation protocol: inclusion of analytes and matrices in an LC-MS/MS sulfonamide residues method [J].
Hoff, Rodrigo Barcellos ;
Barreto, Fabiano ;
Melo, Jessica ;
Martins, Magda Targa ;
Pizzolato, Tania Mara ;
Ruaro Peralba, Maria do Carmo .
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2014, 31 (01) :39-47
[12]   Evolution of a residue laboratory network and the management tools for monitoring its performance [J].
Lins, E. S. ;
Conceicao, E. S. ;
Mauricio, A. De Q. .
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2012, 29 (04) :490-496
[13]  
MAPA, 2011, MANUAL GARANTIA QUAL
[14]   Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS [J].
Matuszewski, BK ;
Constanzer, ML ;
Chavez-Eng, CM .
ANALYTICAL CHEMISTRY, 2003, 75 (13) :3019-3030
[15]   A National Residue Control Plan from the analytical perspective-The Brazilian case [J].
Mauricio, Angelo de Q. ;
Lins, Erick S. ;
Alvarenga, Marcelo B. .
ANALYTICA CHIMICA ACTA, 2009, 637 (1-2) :333-336
[16]   Comparison of the analysis of β-blockers by different techniques [J].
Pujos, E. ;
Cren-Olive, C. ;
Paisse, O. ;
Flament-Waton, M. M. ;
Grenier-Loustalot, M. F. .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2009, 877 (31) :4007-4014
[17]   Simultaneous Detection of Residues of 25 β2-Agonists and 23 β-Blockers in Animal Foods by High-Performance Liquid Chromatography Coupled with Linear Ion Trap Mass Spectrometry [J].
Fan Sai ;
Miao Hong ;
Zhao Yunfeng ;
Chen Huijing ;
Wu Yongning .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2012, 60 (08) :1898-1905
[18]  
Strucinski Pawel, 2007, Rocz Panstw Zakl Hig, V58, P377
[19]   Determination of 15 sedative residues in mutton by rapid resolution liquid chromatography-tandem mass spectrometry [J].
Wei, Jinmei ;
Luo, Yuzhu ;
Zhang, Li ;
Fang, Suli .
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2015, 95 (03) :598-606
[20]   Simultaneous detection of residues of β-adrenergic receptor blockers and sedatives in animal tissues by high-performance liquid chromatography/tandem mass spectrometry [J].
Zhang, Jing ;
Shao, Bing ;
Yin, Jie ;
Wu, Yongning ;
Duan, Hejun .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2009, 877 (20-21) :1915-1922
12