Carotenoids: How Effective Are They to Prevent Age-Related Diseases?

被引：105

作者：

Tan, Bee Ling ^{[1
]}

Norhaizan, Mohd Esa ^{[1
,2
,3
]}

机构：

[1] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Nutr & Dietet, Serdang 43400, Selangor, Malaysia

[2] Univ Putra Malaysia, Inst Biosci, Lab Mol Biomed, Serdang 43400, Selangor, Malaysia

[3] Univ Putra Malaysia, Fac Med & Hlth Sci, Res Ctr Excellent, Nutr & Noncommunicable Dis NNCD, Serdang 43400, Selangor, Malaysia

来源：

MOLECULES | 2019年 / 24卷 / 09期

关键词：

aging; cancer; cardiovascular disease; dementia; diabetes; inflammation; oxidative stress; PIGMENT OPTICAL-DENSITY; OXIDATIVE STRESS; BETA-CAROTENE; CARDIOVASCULAR-DISEASE; DIETARY CAROTENOIDS; VITAMIN-A; MACULAR DEGENERATION; MOLECULAR-MECHANISMS; COGNITIVE FUNCTION; VISUAL IMPAIRMENT;

D O I：

10.3390/molecules24091801

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite an increase in life expectancy that indicates positive human development, a new challenge is arising. Aging is positively associated with biological and cognitive degeneration, for instance cognitive decline, psychological impairment, and physical frailty. The elderly population is prone to oxidative stress due to the inefficiency of their endogenous antioxidant systems. As many studies showed an inverse relationship between carotenoids and age-related diseases (ARD) by reducing oxidative stress through interrupting the propagation of free radicals, carotenoid has been foreseen as a potential intervention for age-associated pathologies. Therefore, the role of carotenoids that counteract oxidative stress and promote healthy aging is worthy of further discussion. In this review, we discussed the underlying mechanisms of carotenoids involved in the prevention of ARD. Collectively, understanding the role of carotenoids in ARD would provide insights into a potential intervention that may affect the aging process, and subsequently promote healthy longevity.

引用

页数：23

共 206 条

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