A facile solvent-free one-pot three-component method for the synthesis of 2-amino-4H-pyrans and tetrahydro-4H-chromenes at ambient temperature

被引：42

作者：

Amirnejad, Meysam ^{[1
]}

Naimi-Jamal, Mohammad Reza ^{[1
]}

Tourani, Hesam ^{[1
]}

Ghafuri, Hossein ^{[1
]}

机构：

[1] Iran Univ Sci & Technol, Dept Chem, Res Lab Green Organ Synth, Tehran 16846, Iran

来源：

MONATSHEFTE FUR CHEMIE | 2013年 / 144卷 / 08期

关键词：

Multi-component reactions (MCRs); One-pot synthesis; Tetrahydro-4H-chromenes; 2-Amino-4H-pyrans; Ball-milling; Solvent-free; MULTICOMPONENT REACTIONS; EFFICIENT SYNTHESIS; GREEN SYNTHESIS; SOLID-STATE; WASTE-FREE; DERIVATIVES; CATALYST; 4H-PYRANS; ACID;

D O I：

10.1007/s00706-013-0938-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-Amino-4H-pyrans and tetrahydro-4H-chromenes were readily prepared via a one-pot, three-component reaction of an aldehyde, malononitrile, and ethyl acetoacetate or 5,5-dimethyl-1,3-cyclohexanedione in the presence of anhydrous piperazine as an efficient and recyclable organocatalyst under solvent-free ball-milling at ambient temperature, with high to quantitative yields.

引用

页码：1219 / 1225

页数：7

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