Serum Antioxidant Concentrations and Metabolic Syndrome Are Associated among U.S. Adolescents in Recent National Surveys

被引:70
作者
Beydoun, May A. [1 ,2 ]
Canas, J. Atilio [3 ]
Beydoun, Hind A. [4 ]
Chen, Xiaoli [5 ]
Shroff, Monal R. [6 ]
Zonderman, Alan B. [1 ,2 ]
机构
[1] NIA, NIH, Baltimore, MD 21224 USA
[2] Intramural Res Program, Baltimore, MD USA
[3] Pediat Endocrinol Diabet & Metab Nemours Children, Jacksonville, FL USA
[4] Eastern Virginia Med Sch, Grad Program Publ Hlth, Norfolk, VA 23501 USA
[5] Johns Hopkins Univ, Dept Int Hlth, Bloomberg Sch Publ Hlth, Ctr Human Nutr, Baltimore, MD USA
[6] Michigan Publ Hlth Inst, Okemos, MI USA
关键词
RETINOL-BINDING-PROTEIN; C-REACTIVE PROTEIN; BETA-CAROTENE SUPPLEMENTATION; NUTRITION EXAMINATION SURVEY; TYPE-2; DIABETES-MELLITUS; ARTERY RISK DEVELOPMENT; BODY-MASS INDEX; INSULIN-RESISTANCE; ALPHA-TOCOPHEROL; VITAMIN-A;
D O I
10.3945/jn.112.160416
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Specific micronutrients, including retinol, retinyl esters, carotenoids beta-carotene, delta-carotene (cis+trans), p-cryptoxanthin, lutein+zeaxanthin, and total lycopene], vitamin E, and vitamin C have antiinflammatory and antioxidant effects, properties shown to reduce oxidative stress, a process that accompanies the pathogenesis of many chronic diseases. It is still largely unknown whether they are associated with the occurrence of metabolic syndrome (MetS) in the adolescent U.S. population. MetS was defined by the International Diabetes Federation (IDF) criteria. Other non-MetS outcomes relying on blood measurements were elevated HOMA-IR, C-reactive protein (CRP), and hyperuricemia. We tested associations between serum antioxidants and MetS outcomes among adolescents aged 12-19 gamma using cross-sectional data from NHANES 2001-2006 (n = 782-4285). IDF MetS prevalence was estimated at 7% among boys and 3% among girls. In adjusted models, adolescents with MetS had consistently lower carotenoid concentrations compared with their counterparts without MetS. Total carotenoids were also inversely related to HOMA-IR and CRP. Vitamin C was inversely related to uric acid level and MetS binary outcome, Retinol+retinyl esters exhibited an inverse relationship with CRP and a positive relationship with uric acid and HOMA-IR as well as MetS binary outcome. Vitamin E had no association with MetS, particularly after controlling for serum cholesterol and TG. In conclusion, among U.S. adolescents, serum carotenoid concentrations were inversely associated with MetS status, HOMA-IR, and CRP, whereas serum vitamin C was inversely related to MetS status and serum uric acid. Vitamin E had no consistent association with MetS, whereas retinol+retinyl esters had a positive relationship with HOMA-IR, uric acid, and MetS, while being inversely related to CRP. These associations need further study. J. Nutr. 142: 1693-1704,2012.
引用
收藏
页码:1693 / 1704
页数:12
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