Synthesis of Superparamagnetic Iron Oxide Nanoparticles Stabilized by Biocompatible Supramolecular β-Cyclodextrin for Biomedical Applications

Superparamagnetic iron oxide nanoparticles have always been a topic of significance in biomedical research due to their tremendous range of applications. The present study reports the synthesis of superparamagnetic Fe2O3 nanoparticles by a simple NaBH4-reduction, stabilised by supramolecular inclusion host beta-cyclodextrin. The crystallite size was calculated from X-ray diffraction studies using Debye Scherrer equation and found to be in the range 14-23 nm. The antibacterial activity of the sample was studied against Vibrio cholerae and Clostridium botulinum using disc diffusion method. Antifungal activity was monitored against three fungal strains Candida auris, Trichophyton rubrum and Cryptococcus gatti using well diffusion method. (C) 2018 Elsevier Ltd. All rights reserved.