Effectiveness of a rehabilitative programme in improving fatigue and function in rheumatoid arthritis patients treated with biologics: a pilot study

被引:0
|
作者
Di Gioia, L. [1 ]
Zincarelli, C. [1 ]
Di Minno, M. N. D. [2 ]
Rengo, G. [3 ]
Peluso, R. [4 ]
Spano, A. [4 ]
Iervolino, S. [1 ]
Pappone, N. [1 ]
机构
[1] Salvatore Maugeri Fdn IRCCS Sci Inst, Rheumatol & Rehabil Res Unit, Telese Terme, BN, Italy
[2] Univ Naples Federico II, Reference Ctr Coagulat Disorders, Dept Clin & Expt Med, Naples, Italy
[3] Salvatore Maugeri Fdn IRCCS Sci Inst, Dept Cardiol, Telese Terme, BN, Italy
[4] Univ Naples Federico II, Rheumatol Res Unit, Dept Clin & Expt Med, Naples, Italy
关键词
rheumatoid arthritis; fatigue; rehabilitation; functional class; CARDIOVASCULAR RISK; EXERCISE; WOMEN; PAIN; FIBROMYALGIA; ASSOCIATION; EFFICACY; THERAPY; FITNESS; DISEASE;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To evaluate the effectiveness of a personalised rehabilitative programme in improving fatigue and function in rheumatoid arthritis (RA) female patients treated with biologic DMARDs. Methods. Thirty-eight consecutive female RA in-patients treated with biologics, entered this prospective pilot study. All subjects were in high disease activity (DAS-28>5.1). After baseline (T0) evaluation, a personalised 4-weeks rehabilitative programme was added to standard biologic treatment and all patients were re-evaluated at the end of the rehabilitative treatment (T1), at 3 (T2), 6 (T3) and 9 (T4) month follow-up. Clinical rheumatologic assessment included the DAS-28, TJC, SJC, global health status, HAQ and FACIT. Results. Subjects showed a mean age of 65 +/- 3.5 years and a 10 +/- 1,1 years mean disease duration. All clinical and laboratory outcomes significantly improved at the different follow-up times as compared to baseline. In particular, a significant improvement in function and fatigue indices (HAQ and FACIT) was found since T1 to T4 as compared to TO. During the follow-up, DAS-28 decreased. Accordingly, about 30% of subjects achieved a moderate disease activity (DAS-28<5.1). Conclusion. A combined treatment biologics-rehabilitation is effective in improving function and fatigue in female patients with established RA. Fatigue results independent from disease activity.
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页码:285 / 288
页数:4
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