Natural killer cells in human health and disease

被引：213
作者：
Orange, JS
Ballas, ZK [1 ]
机构：
[1] Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City VA Med Ctr,Div Allergy & Immunol, Iowa City, IA 52242 USA
[2] Univ Penn, Sch Med, Dept Pediat, Childrens Hosp Philadelphia,Div Allergy & Immunol, Philadelphia, PA 19104 USA
来源：
CLINICAL IMMUNOLOGY | 2006年 / 118卷 / 01期
关键词：
natural killer cells; innate immunity; cytotoxicity; killer cell immunoglobulin-like receptors; immunodeficiency;
D O I：
10.1016/j.clim.2005.10.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Natural killer (NK) cells are lymphocytes of the innate immune system that are critical in host defense and immune regulation. They are activated or inhibited through the ligation of germline-encoded receptors and are involved in mediating cytotoxicity, in producing cytokines and in providing co-stimulation to cells of the adaptive immune system. NK cells play important roles in viral infections, autoimmunity, pregnancy, cancer and bone marrow transplantation. This review highlights recent developments in the understanding of the role of human NK cells in health and disease. Published by Elsevier Inc.
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页码：1 / 10
页数：10
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