Regiospecific microwave-assisted synthesis and cytotoxic activity against human breast cancer cells of (RS)-6-substituted-7-or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or-9H-purines

被引：22

作者：

Conejo-Garcia, Ana ^{[1
]}

Nunez, Maria C. ^{[1
]}

Marchal, Juan A. ^{[2
]}

Rodriguez-Serrano, Fernando ^{[3
]}

Aranega, Antonia ^{[2
]}

Gallo, Miguel A. ^{[1
]}

Espinosa, Antonio ^{[1
]}

Campos, Joaquin M. ^{[1
]}

机构：

[1] Fac Farm, Dept Quim Farmaceut & Organ, Granada 18071, Spain

[2] Fac Med, Dept Anat & Embryol Humana, Granada 18071, Spain

[3] Fac Ciencias Expt, Dept Ciencias Salud, Jaen 23071, Spain

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 43卷 / 08期

关键词：

antitumour compounds; seven-membered rings; microwave; MCF-7; 6-substituted purines;

D O I：

10.1016/j.ejmech.2007.10.025

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Extended studies on the synthesis and pharmacological evaluation of (RS)-6-substituted-7 or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or -9H-purines are presented. The microwave-assisted organic synthesis has provided faster access to the target compounds with the advantage of selective obtaining the N-7 ' or N-9 ' regioisomers simplifying their isolation. To test the behaviour of the products (including the purine bases) on cellular systems, cytotoxic activity against the MCF-7 human breast cancer cell line was determined, and the three most active compounds were used to study the cell cycle distribution and apoptosis in the MCF-7 cell line. (c) 2007 Elsevier Masson SAS. All fights reserved.

引用

页码：1742 / 1748

页数：7

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