The marmoset monkey: a multi-purpose preclinical and translational model of human biology and disease

被引：77

作者：

't Hart, Bert A. ^{[1
]}

Abbott, David H. ^{[2
]}

Nakamura, Katsuki ^{[3
]}

Fuchs, Eberhard ^{[4
]}

机构：

[1] Biomed Primate Res Ctr, Dept Immunobiol, Rijswijk, Netherlands

[2] Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Dept Obstet & Gynecol, Madison, WI 53715 USA

[3] Kyoto Univ, Primate Res Inst, Dept Behav & Brain Sci, Inuyama, Aichi 484, Japan

[4] German Primate Ctr, Clin Neurobiol Lab, Gottingen, Germany

来源：

DRUG DISCOVERY TODAY | 2012年 / 17卷 / 21-22期

关键词：

NONHUMAN PRIMATE MODEL; COMMON MARMOSET; CALLITHRIX-JACCHUS; CHORIONIC-GONADOTROPIN; OVARIAN STIMULATION; MULTIPLE-SCLEROSIS; EXPRESSION; RHESUS; DEXAMETHASONE; PERFORMANCE;

D O I：

10.1016/j.drudis.2012.06.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The development of biologic molecules (monoclonal antibodies, cytokines, soluble receptors) as specific therapeutics for human disease creates a need for animal models in which safety and efficacy can be tested. Models in lower animal species are precluded when the reagents fail to recognize their targets, which is often the case in rats and mice. In this Feature article we will highlight the common marmoset, a small-bodied nonhuman primate (NHP), as a useful model in biomedical and preclinical translational research.

引用

页码：1160 / 1165

页数：6

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