Emerging airway smooth muscle targets to treat asthma

被引：23

作者：

Siddiqui, Sana ^{[1
]}

Redhu, Naresh Singh ^{[2
]}

Ojo, Oluwaseun O. ^{[3
]}

Liu, Bo ^{[4
]}

Irechukwu, Nneka ^{[5
]}

Billington, Charlotte ^{[4
]}

Janssen, Luke ^{[6
]}

Moir, Lyn M. ^{[7
,8
]}

机构：

[1] McGill Univ, Meakins Christie Labs, Dept Med, Montreal, PQ H2X 2P2, Canada

[2] Univ Manitoba, Dept Immunol, Fac Med, Winnipeg, MB R3E0T5, Canada

[3] Univ Manitoba, Dept Resp Physiol, Biol Breathing Grp, Manitoba Inst Child Hlth, Winnipeg, MB R3E 3P4, Canada

[4] Univ Nottingham, Div Therapeut & Mol Med, Queens Med Ctr, Nottingham NG7 2UH, England

[5] Kings Coll London, Dept Asthma & Allergy, Guys Hosp, London SE1 9RT, England

[6] McMaster Univ, Firestone Inst Resp Hlth, St Josephs Hosp, Hamilton, ON L8N 4A6, Canada

[7] Woolcock Inst Med Res, Glebe, NSW 2037, Australia

[8] Univ Sydney, Resp Res Grp, Discipline Pharmacol, Sydney, NSW 2006, Australia

来源：

PULMONARY PHARMACOLOGY & THERAPEUTICS | 2013年 / 26卷 / 01期

基金：

英国医学研究理事会;

关键词：

Asthma; Contraction; Airway hyperreactivity; Kinases; Calcium; GPCRs; IgE; Bronchial thermoplasty; TYROSINE KINASE INHIBITOR; GROWTH-FACTOR RECEPTOR; OPERATED CA2+ ENTRY; FC-EPSILON-RI; OBSTRUCTIVE PULMONARY-DISEASE; ADENOVIRAL GENE-TRANSFER; BITTER TASTE RECEPTORS; GUINEA-PIG MODEL; PHOSPHOINOSITIDE; 3-KINASE; MURINE MODEL;

D O I：

10.1016/j.pupt.2012.08.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Asthma is characterized in part by variable airflow obstruction and non-specific hyperresponsiveness to a variety of bronchoconstrictors, both of which are mediated by the airway smooth muscle (ASM). The ASM is also involved in the airway inflammation and airway wall remodeling observed in asthma. For all these reasons, the ASM provides an important target for the treatment of asthma. Several classes of drugs were developed decades ago which targeted the ASM including beta-agonists, anti-cholinergics, anti-histamines and anti-leukotrienes but no substantially new class of drug has appeared recently. In this review, we summarize the on-going work of several laboratories aimed at producing novel targets and/or tools for the treatment of asthma. These range from receptors and ion channels on the ASM plasma-lemma, to intracellular effectors (particularly those related to cyclic nucleotide signaling, calcium-homeostasis and phosphorylation cascades), to anti-IgE therapy and outright destruction of the ASM itself. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：132 / 144

页数：13

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