PyFluor: A Low-Cost, Stable, and Selective Deoxyfluorination Reagent

被引：218

作者：

Nielsen, Matthew K. ^{[1
]}

Ugaz, Christian R. ^{[1
]}

Li, Wenping ^{[2
]}

Doyle, Abigail G. ^{[1
]}

机构：

[1] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA

[2] Merck Res Labs, Dept Imaging Res, West Point, PA 19486 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 30期

关键词：

DIETHYLAMINOSULFUR TRIFLUORIDE; FLUORINATING AGENT; THERMAL-STABILITY; FLUORIDES; CHEMISTRY; ALCOHOLS; ESTERS; HALOGENATIONS; SUBSTITUTION; CONVERSION;

D O I：

10.1021/jacs.5b06307

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report an inexpensive, thermally stable deoxyfluorination reagent that fluorinates a broad range Of alcohols without substantial formation of elimination side products. This combination of selectivity; safety, and economic viability enables,deoxyfluorination on preparatory scale. We employ the [F-18]-labeled reagent in the first example of a no-carrier-added deoxy-radiofluorination:

引用

页码：9571 / 9574

页数：4

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