A rapid, inexpensive surface treatment for enhanced functionality of polydimethylsiloxane microfluidic channels

被引：39

作者：

Beal, John H. L. ^{[1
]}

Bubendorfer, Andrea ^{[1
]}

Kemmitt, Tim ^{[1
,2
]}

Hoek, Ingrid ^{[1
]}

Arnold, W. Mike ^{[1
,2
]}

机构：

[1] Ind Res Ltd, Nano & Microfluid Team, Lower Hutt 5040, New Zealand

[2] Victoria Univ Wellington, MacDiarmid Inst Adv Mat & Nanotechnol, Wellington 6140, New Zealand

来源：

BIOMICROFLUIDICS | 2012年 / 6卷 / 03期

关键词：

SOL-GEL METHODS; ELECTROOSMOTIC FLOW; POLY(DIMETHYLSILOXANE) MICROCHANNELS; DEVICES; PDMS; FABRICATION; ELECTROPHORESIS; TECHNOLOGY; ABSORPTION; SYSTEMS;

D O I：

10.1063/1.4740232

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A rapid, inexpensive method using alkoxysilanes has been developed to selectively coat the interior of polydimethylsiloxane (PDMS) microfluidic channels with an integral silicaceous layer. This method combines the rapid prototyping capabilities of PDMS with the desirable wetting and electroosmotic properties of glass. The procedure can be carried out on the open faces of PDMS blocks prior to enclosure of the channels, or by flowing the reagents through the preformed channels. Therefore, this methodology allows for high-throughput processing of entire microfluidic devices or selective modification of specific areas of a device. Modification of PDMS with tetraethoxysilane generated a stable surface layer, with enhanced wettability and a more stable electroosmotic flow rate than native PDMS. Modification of PDMS with 3-aminopropyltriethoxysilane generated a surface layer bearing amine functionalities allowing for further chemical derivatization of the PDMS surface. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4740232]

引用

页数：11

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