The Importance of Stochastic Transitions for the Origin of Life

被引：12

作者：

Higgs, Paul G. ^{[1
,2
]}

Wu, Meng ^{[1
,2
]}

机构：

[1] McMaster Univ, Dept Phys & Astron, Hamilton, ON L8S 4M1, Canada

[2] McMaster Univ, Origins Inst, Hamilton, ON L8S 4M1, Canada

来源：

ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES | 2012年 / 42卷 / 05期

关键词：

RNAworld; Autocatalysis; Replicators; Stochastic dynamics; NUCLEOTIDE SYNTHESIS; RIBOZYME; POLYMERIZATION; RECOMBINATION; CATALYSIS;

D O I：

10.1007/s11084-012-9307-0

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We discuss the origin of life in terms of an RNA World scenario in which the creation of autocatalytic sequences is the key step. Our computational models illustrate that life arises by a rare stochastic event that occurs due to spatially localized concentration fluctuations. This allows the chemical system to jump from a non-living state with very low ribozyme concentration to a living state that is controlled by ribozymes. Once the living state is established locally, it can spread deterministically through the rest of the system. These are generic features also possessed by more complex models with a greater degree of chemical realism.

引用

页码：453 / 457

页数：5

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