Understanding enzymic catalysis: The importance of short, strong hydrogen bonds

被引：310
|
作者：
Gerlt, JA
Kreevoy, MM
Cleland, WW
Frey, PA
机构：
[1] UNIV MINNESOTA, DEPT CHEM, MINNEAPOLIS, MN 55455 USA
[2] UNIV WISCONSIN, INST ENZYME RES, MADISON, WI 53706 USA
[3] UNIV WISCONSIN, DEPT BIOCHEM, MADISON, WI 53706 USA
来源：
CHEMISTRY & BIOLOGY | 1997年 / 4卷 / 04期
关键词：
D O I：
10.1016/S1074-5521(97)90069-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have proposed previously that short, strong hydrogen bonds exist in enzyme active sites and that they are important in explaining enzymic rate enhancements. Here, we defend this proposal and provide evidence for likely changes of hydrogen bond strengths during enzymic catalysis.
引用
收藏
页码：259 / 267
页数：9
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