Microbiota, Disease, and Back to Health: A Metastable Journey

被引：236

作者：

Blumberg, Richard ^{[1
]}

Powrie, Fiona ^{[2
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Gastroenterol Div,Dept Med, Boston, MA 02115 USA

[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Med, Translat Gastroenterol Unit,Expt Med Div, Oxford OX3 9DU, England

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2012年 / 4卷 / 137期

基金：

英国惠康基金;

关键词：

INFLAMMATORY BOWEL DISEASES; GUT MICROBIOTA; CLOSTRIDIUM-DIFFICILE; BACTEROIDES-FRAGILIS; INTESTINAL MICROBIOTA; COMMENSAL BACTERIA; IMMUNE-SYSTEM; MOUSE; MICE; PROMOTES;

D O I：

10.1126/scitranslmed.3004184

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alterations in the composition of the commensal microbiota have been observed in many complex diseases. Understanding the basis for these changes, how they relate to disease risk or activity, and the mechanisms by which the symbiotic state of colonization resistance and host homeostasis is restored is critical for future therapies aimed at manipulating the microbiota.

引用

页数：9

共 94 条

[1] The association of Streptococcus bovis/gallolyticus with colorectal tumors: The nature and the underlying mechanisms of its etiological role [J].

Abdulamir, Ahmed S. ;

Hafidh, Rand R. ;

Abu Bakar, Fatimah .

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2011, 30

[2] Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells [J].

Arnold, Isabelle C. ;

Dehzad, Nina ;

Reuter, Sebastian ;

Martin, Helen ;

Becher, Burkhard ;

Taube, Christian ;

Mueller, Anne .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (08) :3088-3093

[3] Narrative review: The new epidemic of clostridium difficile-associated enteric disease [J].

Bartlett, John G. .

ANNALS OF INTERNAL MEDICINE, 2006, 145 (10) :758-764

[4] ESSAY What are the consequences of the disappearing human microbiota? [J].

Blaser, Martin J. ;

Falkow, Stanley .

NATURE REVIEWS MICROBIOLOGY, 2009, 7 (12) :887-894

[5] Commensal Bacteroides Species Induce Colitis in Host-Genotype-Specific Fashion in a Mouse Model of Inflammatory Bowel Disease [J].

Bloom, Seth M. ;

Bijanki, Vinieth N. ;

Nava, Gerardo M. ;

Sun, Lulu ;

Malvin, Nicole P. ;

Donermeyer, David L. ;

Dunne, W. Michael, Jr. ;

Allen, Paul M. ;

Stappenbeck, Thaddeus S. .

CELL HOST & MICROBE, 2011, 9 (05) :390-403

[6] Gut bacteria in health and disease: a survey on the interface between intestinal microbiology and colorectal cancer [J].

Boleij, Annemarie ;

Tjalsma, Harold .

BIOLOGICAL REVIEWS, 2012, 87 (03) :701-730

[7] A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells [J].

Cadwell, Ken ;

Liu, John Y. ;

Brown, Sarah L. ;

Miyoshi, Hiroyuki ;

Loh, Joy ;

Lennerz, Jochen K. ;

Kishi, Chieko ;

Kc, Wumesh ;

Carrero, Javier A. ;

Hunt, Steven ;

Stone, Christian D. ;

Brunt, Elizabeth M. ;

Xavier, Ramnik J. ;

Sleckman, Barry P. ;

Li, Ellen ;

Mizushima, Noboru ;

Stappenbeck, Thaddeus S. ;

Virgin, Herbert W. .

NATURE, 2008, 456 (7219) :259-U62

[8] Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine [J].

Cadwell, Ken ;

Patel, Khushbu K. ;

Maloney, Nicole S. ;

Liu, Ta-Chiang ;

Ng, Aylwin C. Y. ;

Storer, Chad E. ;

Head, Richard D. ;

Xavier, Ramnik ;

Stappenbeck, Thaddeus S. ;

Virgin, Herbert W. .

CELL, 2010, 141 (07) :1135-U64

[9] Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma [J].

Castellarin, Mauro ;

Warren, Rene L. ;

Freeman, J. Douglas ;

Dreolini, Lisa ;

Krzywinski, Martin ;

Strauss, Jaclyn ;

Barnes, Rebecca ;

Watson, Peter ;

Allen-Vercoe, Emma ;

Moore, Richard A. ;

Holt, Robert A. .

GENOME RESEARCH, 2012, 22 (02) :299-306

[10] The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases [J].

Chassaing, Benoit ;

Darfeuille-Michaud, Arlette .

GASTROENTEROLOGY, 2011, 140 (06) :1720-U40

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