Facile synthesis of 2-nitroalkanols by tetramethylguanidine (TMG)-catalyzed addition of primary nitroalkanes to aldehydes and alicyclic ketones

被引：71

作者：

Simoni, D

Invidiata, FP

Manfredini, S

Ferroni, R

Lampronti, I

Roberti, M

Pollini, GP

机构：

[1] UNIV FERRARA,DIPARTIMENTO SCI FARMACEUT,I-44100 FERRARA,ITALY

[2] UNIV BOLOGNA,DIPARTIMENTO SCI FARMACEUT,I-40126 BOLOGNA,ITALY

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(97)00461-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tetramethylguanidine-catalyzed addition of primary nitroalkanes to aldehydes and alicyclic ketones constitutes a practical means to perform the nitro-aldol reaction (Henry reaction). The very mild conditions employed, together with the short reaction times, make the procedure tolerant of a range of functionalities and highly versatile for the synthesis of a variety of 2-nitroalkanols. (C) 1997 Elsevier Science Ltd.

引用

页码：2749 / 2752

页数：4