Effects of Luteolin and Quercetin in Combination with Some Conventional Antibiotics against Methicillin-Resistant Staphylococcus aureus

被引：56
作者：
Amin, Muhammad Usman [1 ,7 ]
Khurram, Muhammad [2 ]
Khan, Taj Ali [1 ]
Faidah, Hani S. [3 ]
Shah, Zia Ullah [4 ]
Rahman, Shafiq Ur [2 ]
Haseeb, Abdul [5 ]
Ilyas, Muhammad [4 ]
Ullah, Naseem [6 ]
Khayam, Sahibzada Muhammad Umar [6 ]
Iriti, Marcello [8 ]
机构：
[1] Kohat Univ Sci & Technol, Dept Microbiol, Kohat 26000, Pakistan
[2] Shaheed Benazir Bhutto Univ, Dept Pharm, Sheringal 18000, Pakistan
[3] Umm Al Qura Univ, Dept Microbiol, Fac Med, Mecca 21955, Saudi Arabia
[4] Sarhad Univ Sci & Informat Technol, Dept Microbiol Biotechnol, Peshawar 25000, Pakistan
[5] Umm Al Qura Univ, Dept Clin Pharm, Coll Pharm, Mecca 21955, Saudi Arabia
[6] Sarhad Univ Sci & Informat Technol, Dept Pharm, Peshawar 25000, Pakistan
[7] Khyber Med Univ, Dept Pharmacol, Inst Med Sci, Kohat 26000, Pakistan
[8] Milan State Univ, Dept Agr & Environm Sci, I-20133 Milan, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 11期
关键词：
flavonoids; antibiotic resistance; MRSA; combination therapy; synergism; phytochemicals; IN-VITRO; ANTIBACTERIAL ACTIVITIES; ANTIMICROBIAL ACTIVITY; SYNERGISTIC ACTIVITY; NATURAL FLAVONOIDS; CELL-WALL; CATECHIN; ANTIOXIDANT; STRAINS; GALLATE;
D O I：
10.3390/ijms17111947
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The present study was designed to evaluate the effects of flavonoids luteolin (L) and quercetin + luteolin (Q + L) in combination with commonly used antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates and S. aureus (ATCC 43300). Minimum inhibitory concentrations (MICs) of L and Q + L, as well as the MICs of flavonoids in combination with antibiotics were determined and results showed an increased activity of flavonoids with antibiotics. The synergistic, additive, or antagonistic relationships between flavonoids (L and Q + L) and antibiotics were also evaluated, and additive and synergistic effects were observed for some antibiotic + flavonoid combinations. In addition, some combinations were also found to damage the bacterial cytoplasmic membrane, as assessed through potassium leakage assay. The effects of flavonoids and flavonoids + antibiotics on mecA gene mutations were also tested, and no functional variation was detected in the coding region.
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页数：16
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