Cyclooxygenase-2 (COX-2) as a Target of Anticancer Agents: A Review of Novel Synthesized Scaffolds Having Anticancer and COX-2 Inhibitory Potentialities

被引：28
作者：
Mohsin, Noor Ul Amin [1 ]
Aslam, Sana [2 ]
Ahmad, Matloob [3 ]
Irfan, Muhammad [4 ]
Al-Hussain, Sami A. [5 ]
Zaki, Magdi E. A. [5 ]
机构：
[1] Govt Coll Univ, Fac Pharmaceut Sci, Dept Pharmaceut Chem, Faisalabad 38000, Pakistan
[2] Govt Coll Women Univ, Dept Chem, Faisalabad 38000, Pakistan
[3] Govt Coll Univ, Dept Chem, Faisalabad 38000, Pakistan
[4] Govt Coll Univ, Fac Pharmaceut Sci, Dept Pharmaceut, Faisalabad 38000, Pakistan
[5] Imam Mohammad Ibn Saud Islamic Univ IMSIU, Fac Sci, Dept Chem, Riyadh 11623, Saudi Arabia
来源：
PHARMACEUTICALS | 2022年 / 15卷 / 12期
关键词：
drug design; hybrid molecules; cancer cell lines; molecular docking; COX-2; IN-VITRO; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; DUAL INHIBITORS; ANTITUMOR ACTIVITIES; NATURAL-PRODUCTS; CANCER; DERIVATIVES; DESIGN; DISCOVERY;
D O I：
10.3390/ph15121471
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cancer is a serious threat to human beings and is the second-largest cause of death all over the globe. Chemotherapy is one of the most common treatments for cancer; however, drug resistance and severe adverse effects are major problems associated with anticancer therapy. New compounds with multi-target inhibitory properties are targeted to surmount these challenges. Cyclooxygenase-2 (COX-2) is overexpressed in cancers of the pancreas, breast, colorectal, stomach, and lung carcinoma. Therefore, COX-2 is considered a significant target for the synthesis of new anticancer agents. This review discusses the biological activity of recently prepared dual anticancer and COX-2 inhibitory agents. The most important intermolecular interactions with the COX-2 enzyme have also been presented. Analysis of these agents in the active area of the COX-2 enzyme could guide the introduction of new lead compounds with extreme selectivity and minor side effects.
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页数：41
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