Combined hormonal influence of cyproterone acetate and nomegestrol acetate on meningioma: a case report

被引：17
作者：
Champagne, Pierre-Olivier [1 ,2 ]
Passeri, Thibault [1 ]
Froelich, Sebastien [1 ]
机构：
[1] Paris VII Diderot Univ, Hop Lariboisiere, Dept Neurosurg, 2 Rue Ambroise Pare, F-75475 Paris, France
[2] Univ Paris Diderot, Lariboisiere Hosp, Dept Neurosurg, 2 Rue Ambroise Pare, F-75010 Paris, France
来源：
ACTA NEUROCHIRURGICA | 2019年 / 161卷 / 03期
关键词：
Cyproterone acetate; Nomegestrol acetate; Meningioma; Hormone therapy; DISCONTINUATION; REGRESSION; RISK;
D O I：
10.1007/s00701-018-03782-4
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Cyproterone acetate (CPA) is an antiandrogenic drug which has recently been recognized to promote the occurrence and growth of intracranial meningiomas. Nomegestrol acetate (NOMAC) is a widely used progestin-like drug that could be suggested as an alternative for patients taking CPA. We report a case of CPA-related meningioma for which relay from CPA to NOMAC led to further tumor growth and cessation of NOMAC-induced tumor shrinkage. We suggest NOMAC can have a similar effect than CPA on meningiomas. The use of NOMAC as replacement for CPA in the presence of a meningioma should be discouraged until further evidence becomes available on the role of NOMAC in such instances.
引用
收藏
页码：589 / 592
页数：4
相关论文
共 24 条
[1]  
[Anonymous], 2008, Endocrine Abstracts
[2]   Growth stabilization and regression of meningiomas after discontinuation of cyproterone acetate: a case series of 12 patients [J].
Bernat, Anne Laure ;
Oyama, Kenichi ;
Hamdi, Selma ;
Mandonnet, Emmanuel ;
Vexiau, Dominique ;
Pocard, Marc ;
George, Bernard ;
Froelich, Sebastien .
ACTA NEUROCHIRURGICA, 2015, 157 (10) :1741-1746
[3]   Should patients with lymphangioleiomyomatosis undergo screening for meningioma? [J].
Cottin, V ;
Vukusic, S ;
Jouanneau, E ;
Lazor, R ;
Cordier, X .
EUROPEAN RESPIRATORY JOURNAL, 2004, 24 (05) :888-889
[4]  
Durmaz R, 1999, ARCH PHYSIOL BIOCHEM, V107, P286, DOI 10.1076/1381-3455(199908)107:04
[5]  
1-Q
[6]  
FT286
[7]   Risk of meningioma among users of high doses of cyproterone acetate as compared with the general population: evidence from a population-based cohort study [J].
Gil, Miguel ;
Oliva, Belen ;
Timoner, Julia ;
Macia, Miguel A. ;
Bryant, Veronica ;
de Abajo, Francisco J. .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2011, 72 (06) :965-968
[8]   Abrupt Regression of a Meningioma after Discontinuation of Cyproterone Treatment [J].
Goncalves, A. M. G. ;
Page, P. ;
Domigo, V. ;
Mader, J. -F. ;
Oppenheim, C. .
AMERICAN JOURNAL OF NEURORADIOLOGY, 2010, 31 (08) :1504-1505
[9]   Drug Treatment of Paraphilic and Nonparaphilic Sexual Disorders [J].
Guay, David R. P. .
CLINICAL THERAPEUTICS, 2009, 31 (01) :1-31
[10]   Meningioma in untreated congenital adrenal hyperplasia: a relationship? [J].
Heijboer, Annemieke C. ;
Netelenbos, J. Coen ;
Blankenstein, Marinus A. .
JOURNAL OF NEURO-ONCOLOGY, 2009, 92 (02) :223-225
123