Association between MMP-12-82A/G polymorphism and cancer risk: a meta-analysis

被引:1
|
作者
Liu, Luliang [1 ]
Sun, Jinhuan [2 ]
Li, Guolin [1 ]
Gu, Boyu [1 ]
Wang, Xiaolong [1 ]
Chi, Huirong [1 ]
Guo, Fulin [1 ]
机构
[1] Harbin Med Univ, Affiliated Hosp 1, Dept Oral & Maxillofacial Surg, Harbin, Heilongjiang, Peoples R China
[2] Harbin Med Univ, Affiliated Hosp 1, Dept Periodontol, Harbin, Heilongjiang, Peoples R China
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2015年 / 8卷 / 08期
关键词
Matrix metalloproteinases-12; polymorphism; cancer risk; meta-analysis; MATRIX-METALLOPROTEINASE; FUNCTIONAL POLYMORPHISMS; PROMOTER REGION; EXPRESSION; INVASION; TUMOR; HEAD; INVASIVENESS; ANGIOSTATIN; CARCINOMA;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: Numerous studies have focused on the association between MMP-12-82A>G polymorphism and cancer risk, but produced inconsistent results. Therefore, we performed a meta-analysis of case-control study to evaluate the association of MMP-12-82A>G polymorphism and cancer risk. Methods: A systematic literature search was conducted among PubMed, Web of Science, Science Direct, China National Knowledge Infrastructure (CNKI) and Wangfang databases updated on May 1st, 2015. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of association between this polymorphism and cancer risk. Results: A total of seventeen case-control studies with 7,450 cases and 7,348 controls were identified and analyzed. Overall, there was no statistically significant association between MMP-12-82A>G polymorphism and increased risk of cancer under all genetic models. Subgroup analysis by ethnicity observed that there is no strong relationship between MMP-12-82A>G polymorphism and cancer risk among Asian and European populations. Furthermore, stratified analysis based on the source of control revealed no statistically significant association between MMP-12-82A>G polymorphism and cancer risk either in hospital-based or population-based studies. However, when we stratified analysis based on cancer type, significant association was found in ovarian cancer, but not in other types of cancer. Conclusion: This meta-analysis suggests that MMP-12-82A>G polymorphism is not significantly associated with overall cancer risk. However, MMP-12-82A>G polymorphism may increase the susceptibility to ovarian cancer.
引用
收藏
页码:11896 / 11904
页数:9
相关论文
共 50 条
  • [1] The association between MMP-12 82 A/G polymorphism and susceptibility to various malignant tumors: a meta-analysis
    Chen, Sheng-Song
    Song, Juan
    Tu, Xiao-Yun
    Zhao, Ji-Hua
    Ye, Xiao-Qun
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (07): : 10845 - 10854
  • [2] Association between EGF +61 A>G polymorphism and gastric cancer risk: A meta-analysis
    Song-jie Wu
    Si-yu Jiang
    Jing Wu
    Guang-lian Xiong
    Journal of Huazhong University of Science and Technology [Medical Sciences], 2015, 35 : 327 - 332
  • [3] Association between the COMT 158 G/A polymorphism and lung cancer risk: a meta-analysis
    Peng, Shifeng
    Tong, Xiang
    Liu, Sitong
    Feng, Yulin
    Fan, Hong
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (10): : 17739 - 17747
  • [4] Association between ATM 5557G>A polymorphism and breast cancer risk: a meta-analysis
    Chen Mao
    Vincent C. H. Chung
    Ben-Fu He
    Rong-Cheng Luo
    Jin-Ling Tang
    Molecular Biology Reports, 2012, 39 : 1113 - 1118
  • [5] Association Between IL-17A+197 G/A Polymorphism and Cancer Risk: A Meta-analysis
    Lu, Yunjie
    Gu, Jian
    Lu, Hao
    Zhu, Qing
    Zhang, Feng
    Wang, Xuehao
    Lu, Ling
    Zhang, Chuanyong
    GENETIC TESTING AND MOLECULAR BIOMARKERS, 2016, 20 (01) : 24 - 30
  • [6] Association between ATM polymorphism and the risk of thyroid cancer: a meta-analysis
    Yu, Hui
    Duan, Yong-Qiang
    Zhang, Chi
    Zhang, Jie-Rong
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2017, 10 (10): : 14869 - 14875
  • [7] Meta-Analysis of the Association between the IL-12B+1188 A/C Polymorphism and Cancer Risk
    Yang, Zaixing
    Liang, Yan
    Qin, Baodong
    Zhong, Renqian
    ONKOLOGIE, 2013, 36 (09): : 470 - 475
  • [8] Association between MPO 463G>A polymorphism and risk of lung cancer: a meta-analysis
    Zhou, Chengzhi
    Luo, Qun
    Qing, Yinyin
    Lin, Xinqing
    Zhan, Yangqin
    Ouyang, Ming
    TUMOR BIOLOGY, 2013, 34 (06) : 3449 - 3455
  • [9] Association between ATM 5557G>A polymorphism and breast cancer risk: a meta-analysis
    Mao, Chen
    Chung, Vincent C. H.
    He, Ben-Fu
    Luo, Rong-Cheng
    Tang, Jin-Ling
    MOLECULAR BIOLOGY REPORTS, 2012, 39 (02) : 1113 - 1118
  • [10] Association between survivin −31G>C promoter polymorphism and cancer risk: a meta-analysis
    Xiefeng Wang
    Lili Huang
    Yanjie Xu
    Zhumei Shi
    Yingyi Wang
    Junxia Zhang
    Xirui Wang
    Lei Cao
    Hui Luo
    Jiawei Chen
    Ning Liu
    Yongmei Yin
    Yongping You
    European Journal of Human Genetics, 2012, 20 : 790 - 795