Chromium and zinc concentrations in pediatric patients receiving long-term parenteral nutrition

被引:11
作者
Mouser, JF
Hak, EB
Helms, RA
Christensen, ML
Storm, MC
机构
[1] Univ Tennessee, Dept Clin Pharm, Memphis, TN 38163 USA
[2] Univ Connecticut, Dept Pharm Practice, Storrs, CT USA
关键词
amino acids; blood levels; chromium; cysteine hydrochloride; dosage schedules; drug interactions; elements; nutrition; pediatrics; urine levels; zinc;
D O I
10.1093/ajhp/56.19.1950
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Serum, urine, and parenteral nutrition (PN) chromium and zinc concentrations in pediatric patients receiving long-term PN were studied. Serum, urine, and PN chromium and zinc concentrations were measured at baseline and four to six months later in four infants (less than 1 year old) and seven children (1-12 years old) receiving long-term PN. In the children, serum, urine, and PN solution zinc concentrations were measured monthly after the amino acid product was changed from a standard to a pediatric product with monthly dosages of 0, 20, 30, and 40 mg of cysteine hydrochloride per gram of amino acids. The mean +/- S.D. baseline serum chromium concentration was 4.9 +/- 1.9 mu g/L (normal value, <0.3 mu g/L); the urine chromium concentration ranged from 3.4 to 32.2 mu g/L. The mean +/- S.D. prescribed chromium dosage was 0.18 +/- 0.05 mu g/kg/day, and the dosage delivered in PN solutions was 0.41 +/- 0.23 mu g/ kg/day. At baseline, the mean +/- S.D, serum zinc concentration was 1383 +/- 472 mu g/L (normal range, 430 to 940 mu g/ L), and the prescribed and delivered zinc dosages were 177 +/- 10 and 238 +/- 145 mu g/kg/ day, respectively. With 20, 30, and 40 mg of cysteine per gram of amino acids, the mean +/- S.D. serum zinc concentration was 1728 +/- 782, 1664 +/- 349, and 1685 +/- 268 mu g/L, respectively, and the actual zinc dosages delivered were 209 +/- 10, 270 +/- 148, and 322 +/- 194 mu g/kg/day, respectively. Serum and urine chromium concentrations were abnormally high in infants and children receiving PN solutions supplemented with normal doses of these trace elements; an escalating dosage of cysteine in the children tended to increase serum and urine zinc concentrations.
引用
收藏
页码:1950 / 1956
页数:7
相关论文
共 26 条
[1]   EFFECTS OF CHROMIUM SUPPLEMENTATION ON URINARY CR EXCRETION OF HUMAN-SUBJECTS AND CORRELATION OF CR EXCRETION WITH SELECTED CLINICAL-PARAMETERS [J].
ANDERSON, RA ;
POLANSKY, MM ;
BRYDEN, NA ;
PATTERSON, KY ;
VEILLON, C ;
GLINSMANN, WH .
JOURNAL OF NUTRITION, 1983, 113 (02) :276-281
[2]  
ANDERSON RA, 1995, NUTRITION, V11, P83
[3]   PLASMA CHROMIUM CONCENTRATIONS IN NORMAL INFANTS AND CYSTIC-FIBROSIS PATIENTS [J].
BOUGLE, D ;
BUREAU, F ;
VOIRIN, J ;
NEUVILLE, D ;
DROSDOWSKY, M ;
DUHAMEL, JF .
BIOLOGICAL TRACE ELEMENT RESEARCH, 1992, 32 :53-55
[4]   CHROMIUM STATUS OF FULL-TERM AND PRETERM NEWBORNS [J].
BOUGLE, D ;
BUREAU, F ;
VOIRIN, J ;
NEUVILLE, D ;
DROSDOWSKY, M ;
DUHAMEL, JF .
BIOLOGICAL TRACE ELEMENT RESEARCH, 1992, 32 :47-51
[5]   CHROMIUM AND PARENTERAL-NUTRITION IN CHILDREN [J].
BOUGLE, D ;
BUREAU, F ;
DESCHREVEL, G ;
HECQUARD, C ;
NEUVILLE, D ;
DROSDOWSKY, M ;
DUHAMEL, JF .
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 1993, 17 (01) :72-74
[6]   CHROMIUM DEFICIENCY AFTER LONG-TERM TOTAL PARENTERAL-NUTRITION [J].
BROWN, RO ;
FORLOINESLYNN, S ;
CROSS, RE ;
HEIZER, WD .
DIGESTIVE DISEASES AND SCIENCES, 1986, 31 (06) :661-664
[7]   SERUM TRACE-ELEMENTS IN CHILDREN RECEIVING LONG-TERM PARENTERAL-NUTRITION [J].
DAHLSTROM, KA ;
AMENT, ME ;
MEDHIN, MG ;
MEURLING, S .
JOURNAL OF PEDIATRICS, 1986, 109 (04) :625-630
[8]   CHROMIUM DEFICIENCY DURING TOTAL PARENTERAL NUTRITION [J].
FREUND, H ;
ATAMIAN, S ;
FISCHER, JE .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1979, 241 (05) :496-498
[9]  
GREENE HL, 1988, AM J CLIN NUTR, V48, P1324
[10]   Chromium and zinc contamination of parenteral nutrient solution components commonly used in infants and children [J].
Hak, EB ;
Storm, MC ;
Helms, RA .
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 1998, 55 (02) :150-154