Ginkgo biloba (EGb 761) Extract: Effects on the Myenteric Plexus of the Large Intestine in Wistar Rats

被引：3
作者：
Perez, Glasiella Gonzalez [1 ]
Lauer Schneider, Larissa Carla [1 ]
Buttow, Nilza Cristina [1 ]
机构：
[1] Univ Estadual Maringa, Dept Morphophysiol Sci, BR-87020900 Maringa, Parana, Brazil
来源：
DIGESTIVE DISEASES AND SCIENCES | 2009年 / 54卷 / 02期
关键词：
Ageing; Ginkgo biloba; Myenteric plexus; Neurotrophic effect; GASTROINTESTINAL-TRACT; NEURONS; NUMBER; EXPRESSION; AGE;
D O I：
10.1007/s10620-008-0338-3
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The objective of this study was to evaluate the effect of the purified extract of the Ginkgo biloba (EGb 761) plant on the myenteric plexus in the proximal and distal colon of Wistar rats for a period of 120 days. The experimental rats were divided into two age groups: a young group, sacrificed at age 90 days, and an adult group, sacrified at age 210 days. We observed a significant reduction in the number of neurons in the myenteric plexus of the adult group compared to the young group in both of the segments studied (P < 0.01). The adult group treated with Ginkgo biloba showed a significant increase in neuronal profile area in both the segments studied (P < 0.001). It can be concluded from these results that treatment with the purified Ginkgo biloba (EGb 761) plant extract at a dose of 50 mg/kg body weight has neurotrophic effect on the myenteric plexus in the proximal and distal colon of rats after 120 days of treatment.
引用
收藏
页码：232 / 237
页数：6
相关论文
共 29 条
  • [1] Substance P enhances neuronal area and epithelial cell proliferation after colon denervation in rats
    Buttow, NC
    Zucoloto, S
    Espreafico, EM
    Gama, P
    Alvares, EP
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2003, 48 (10) : 2069 - 2076
  • [2] Neuroprotective effects of Ginkgo biloba extract in brain ischemia are mediated by inhibition of nitric oxide synthesis
    Calapai, G
    Crupi, A
    Firenzuoli, F
    Marciano, MC
    Squadrito, F
    Inferrera, G
    Parisi, A
    Rizzo, A
    Crisafulli, C
    Fiore, A
    Caputi, AP
    [J]. LIFE SCIENCES, 2000, 67 (22) : 2673 - 2683
  • [3] NEUROBIOLOGY OF THE INTESTINAL-MUCOSA
    COOKE, HJ
    [J]. GASTROENTEROLOGY, 1986, 90 (04) : 1057 - 1081
  • [4] EFFECT OF CHEMICAL ABLATION OF MYENTERIC NEURONS ON NEUROTRANSMITTER LEVELS IN THE RAT JEJUNUM
    DAHL, JL
    BLOOM, DD
    EPSTEIN, ML
    FOX, DA
    BASS, P
    [J]. GASTROENTEROLOGY, 1987, 92 (02) : 338 - 344
  • [5] FALL IN THE NUMBER OF MYENTERIC NEURONS IN AGING GUINEA-PIGS
    GABELLA, G
    [J]. GASTROENTEROLOGY, 1989, 96 (06) : 1487 - 1493
  • [6] A preliminary investigation of the effects of aging on the nerve cell number in the myenteric ganglia of the human colon
    Gomes, OA
    deSouza, RR
    Liberti, EA
    [J]. GERONTOLOGY, 1997, 43 (04) : 210 - 217
  • [7] Aging: Overview
    Harman, D
    [J]. HEALTHY AGING FOR FUNCTIONAL LONGEVITY: MOLECULAR AND CELLULAR INTERACTIONS IN SENESCENCE, 2001, 928 : 1 - 21
  • [8] The effects of age on the overall population and on subpopulations of myenteric neurons in the rat small intestine
    Johnson, RJR
    Schemann, M
    Santer, RM
    Cowen, T
    [J]. JOURNAL OF ANATOMY, 1998, 192 : 479 - 488
  • [9] Reducing equivalents in the aging process
    Kohen, R
    Fanberstein, D
    Tirosh, O
    [J]. ARCHIVES OF GERONTOLOGY AND GERIATRICS, 1997, 24 (02) : 103 - 123
  • [10] Evaluation of the effect of Ginkgo biloba extract (EGb 761) on the myenteric plexus of the small intestine of Wistar rats
    Lauer Schneider, Larissa Carla
    Perez, Glasiella Gonsales
    Banzi, Silmara Reis
    Zanoni, Jacqueline Nelisis
    Marcal Natali, Maria Raquel
    Buttow, Nilza Cristina
    [J]. JOURNAL OF GASTROENTEROLOGY, 2007, 42 (08) : 624 - 630
123