Complex upper arm reconstruction using an antero-lateral thigh free flap after an extravasation of Yttrium-90-ibritumomab Tiuxetan: A case report and literature review

被引：11

作者：

Baus, A. ^{[1
,4
]}

Keilani, C. ^{[1
,4
]}

Bich, C. -S. ^{[1
]}

Entine, F. ^{[2
]}

Brachet, M. ^{[1
]}

Duhamel, P. ^{[1
]}

Amabile, J. -C. ^{[2
]}

Malfuson, J. V. ^{[3
]}

Bey, E. ^{[1
]}

机构：

[1] Percy Mil Hosp, Plast Surg Unit, F-92140 Clamart, France

[2] Percy Mil Hosp, French Army Radiat Protect Unit, F-92140 Clamart, France

[3] Percy Mil Hosp, Hematol Unit, F-92140 Clamart, France

[4] Fac Med Pierre & Marie Curie, F-75252 Paris 05, France

来源：

ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE | 2018年 / 63卷 / 02期

关键词：

Localized irradiation; Ibritumomab tiuxetanyttrium 90; Monoclonal antibodies; Extravasation; Iatrogenic complication; Antero-lateral thigh free flap; CUTANEOUS RADIATION SYNDROME; MANAGEMENT; THERAPY;

D O I：

10.1016/j.anplas.2017.11.007

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Yttrium-90-Ibritumomab Tiuxetan (Zevalin (R)) is used in the treatment of non-Hodgkin's lymphoma. Extravasation is an iatrogenic complication that is fortunately rare. However, the treatment of this complication is often complex due to the risk of extensive skin necrosis and unpredictable evolution of localized irradiation. This vesicant drug requires emergency management when extravasation occured. Radiations burns have specificities. Therefore, wound coverage involves specific plastic surgical techniques. Here, we report the case of a man presenting a chronic and extensive skin necrosis of upper arm treated with an antero-lateral thigh free flap. Moreover, we compare our experience of Zevalin (R) extravasation management to other past publications and propose recommendations to prevent this unacceptable complication. (C) 2017 Elsevier Masson SAS. All rights reserved.

引用

页码：175 / 181

页数：7

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