Investigation of chromosome 9q22.3-q31 DNA marker loss in odontogenic keratocysts

被引：52

作者：

Lench, NJ ^{[1
]}

High, AS ^{[1
]}

Markham, AF ^{[1
]}

Hume, WJ ^{[1
]}

Robinson, PA ^{[1
]}

机构：

[1] ST JAMES UNIV HOSP,MOLEC MED UNIT,LEEDS LS9 7TF,W YORKSHIRE,ENGLAND

来源：

ORAL ONCOLOGY-EUROPEAN JOURNAL OF CANCER PART B | 1996年 / 32B卷 / 03期

基金：

英国惠康基金;

关键词：

chromosome; 9q; loss of heterozygosity; NBCCS; odontogenic keratocyst;

D O I：

10.1016/0964-1955(95)00053-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multiple basal cell carcinomas and odontogenic keratocysts of the jaws are a feature of the inherited naevoid basal cell carcinoma syndrome (NBCCS), although both occur more commonly as single, sporadic cases. The NBCCS gene has been mapped to chromosome 9q22.3-q31 and loss of heterozygosity for DNA markers from this region has been observed in familial and sporadic basal cell carcinomas. Based on these observations, we undertook a pilot study to determine if a similar pattern of chromosome loss occurs in odontogenic keratocysts. DNA extracted from microdissected odontogenic keratocyst epithelium was examined for loss of heterozygosity for six polymorphic DNA markers mapping to human chromosome 9q22.3-q31. Allelotype loss was detected in epithelium from three, single, sporadic odontogenic keratocysts. These results implicate homozygous inactivation of the NBCCS gene in the initiation and progression of the odontogenic keratocyst. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：202 / 206

页数：5

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