Platelets and Platelet-Derived Extracellular Vesicles in Liver Physiology and Disease

被引：29

作者：

Balaphas, Alexandre ^{[1
,2
,3
]}

Meyer, Jeremy ^{[1
,2
,3
]}

Sadoul, Karin ^{[4
]}

Fontana, Pierre ^{[5
,6
]}

Morel, Philippe ^{[1
,2
,3
]}

Gonelle-Gispert, Carmen ^{[2
,3
]}

Bueler, Leo H. ^{[1
,2
,3
]}

机构：

[1] Geneva Univ Hosp, Div Digest Surg, Rue Gabrielle Perret Genbtil 4, CH-1211 Geneva, Switzerland

[2] Geneva Univ Hosp, Surg Res Unit, Geneva, Switzerland

[3] Univ Geneva, Geneva Med Sch, Geneva, Switzerland

[4] Univ Grenoble Alpes, Inst Adv Biosci, Regulat & Pharmacol Cytoskeleton, Grenoble, France

[5] Geneva Univ Hosp, Div Angiol & Hemostasis, Geneva, Switzerland

[6] Univ Geneva, Geneva Platelet Grp, Geneva, Switzerland

来源：

HEPATOLOGY COMMUNICATIONS | 2019年 / 3卷 / 07期

基金：

瑞士国家科学基金会;

关键词：

SINUSOIDAL ENDOTHELIAL-CELL; MICROPARTICLES INDUCE ANGIOGENESIS; HEPATIC STELLATE CELLS; CANCER-CELLS; PROCOAGULANT MICROPARTICLES; CIRCULATING MICROPARTICLES; HEPATOCELLULAR-CARCINOMA; INTERNATIONAL SOCIETY; ACTIVATED PLATELETS; PARTIAL-HEPATECTOMY;

D O I：

10.1002/hep4.1358

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Beyond their role in hemostasis, platelets are proposed as key mediators of several physiological and pathophysiological processes of the liver, such as liver regeneration, toxic or viral acute liver injury, liver fibrosis, and carcinogenesis. The effects of platelets on the liver involve interactions with sinusoidal endothelial cells and the release of platelet-contained molecules following platelet activation. Platelets are the major source of circulating extracellular vesicles, which are suggested to play key roles in platelet interactions with endothelial cells in several clinical disorders. In the present review, we discuss the implications of platelet-derived extracellular vesicles in physiological and pathophysiological processes of the liver.

引用

页码：855 / 866

页数：12

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