Novel Tragacanth Gum-Entrapped lecithin nanogels for anticancer drug delivery

被引：26

作者：

Verma, Chetna ^{[1
,2
]}

Negi, Poonam ^{[3
]}

Pathania, Deepak ^{[4
]}

Anjum, Sadiya ^{[2
]}

Gupta, Bhuvanesh ^{[2
]}

机构：

[1] Shoolini Univ, Dept Chem, Solan, India

[2] Indian Inst Technol, Bioengn Lab, Dept Text Technol, New Delhi, India

[3] Shoolini Univ, Dept Pharm, Solan 173212, Himachal Prades, India

[4] Cent Univ Jammu, Dept Environm Sci, Jammu, Jammu & Kashmir, India

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2020年 / 69卷 / 09期

关键词：

Cisplatin; lecithin; nanoemulsion; nanogel; tragacanth gum; CONTROLLED-RELEASE; CISPLATIN; NANOHYDROGELS; HYDROGEL; SYSTEM; ACID;

D O I：

10.1080/00914037.2019.1596910

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Nanogels are functional particles that may be used to deliver bioactive molecules in targeted drug delivery systems. In the present work, we have investigated the preparation of cisplatin (CP) loaded Tragacanth Gum (TG)-lecithin (LC) nanogels by nanoemulsion process. These nanogels exhibit polygonal core-shell structure in which CP particles are embedded in the TG core of the nanogels and remain covered by LC as shell. Varying concentration of CP were added in the nanogel and the shape and size of the nanogels was investigated. Nanogels were characterized by dynamic light scattering analysis as well. Sustained release of CP from the CP-loaded nTG-LC nanogels as drug was observed in controlled manner under physiological saline.

引用

页码：604 / 609

页数：6

共 24 条

[1] Tunable Biodegradable Nanocomposite Hydrogel for Improved Cisplatin Efficacy on HCT-116 Colorectal Cancer Cells and Decreased Toxicity in Rats
Abdel-Bar, Hend Mohamed
Osman, Rihab
Abdel-Reheem, Amal Youssef
Mortada, Nahed
Awad, Gehanne A. S.
[J]. BIOMACROMOLECULES, 2016, 17 (02) : 407 - 414
[2] Defining cisplatin incorporation properties in thermosensitive injectable biodegradable hydrogel for sustained delivery and enhanced cytotoxicity
Abdel-Bar, Hend Mohamed
Abdel-Reheem, Amal Youssef
Osman, Rihab
Awad, Gehanne A. S.
Mortada, Nahed
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2014, 477 (1-2) : 623 - 630
[3] Bioengineering of Functional Nanosilver Nanogels for Smart Healthcare Systems
Anjum, Sadiya
Gupta, Bhuvanesh
[J]. GLOBAL CHALLENGES, 2018, 2 (10)
[4] Skin compatibility and antimicrobial studies on biofunctionalized polypropylene fabric
Anjum, Sadiya
Gupta, Amlan
Sharma, Deepika
Dalal, Prashansa
Gupta, Bhuvanesh
[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2016, 69 : 1043 - 1050
[5] Development of novel wound care systems based on nanosilver nanohydrogels of polymethacrylic acid with Aloe vera and curcumin
Anjum, Sadiya
Gupta, Amlan
Sharma, Deepika
Gautam, Deepti
Bhan, Surya
Sharma, Anupama
Kapil, Arti
Gupta, Bhuvanesh
[J]. MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2016, 64 : 157 - 166
[6] Blount R. P, 2016, GELS HDB FUNDAMENTAL, P35, DOI [10.1142/9789813140417_0002, DOI 10.1142/9789813140417_0002]
[7] Polymer micelles with cross-linked ionic cores for delivery of anticancer drugs
Bontha, Satya
Kabanov, Alexander V.
Bronich, Tatiana K.
[J]. JOURNAL OF CONTROLLED RELEASE, 2006, 114 (02) : 163 - 174
[8] Modified biopolymer-dextrin based crosslinked hydrogels: application in controlled drug delivery
Das, Dipankar
Pal, Sagar
[J]. RSC ADVANCES, 2015, 5 (32) : 25014 - 25050
[9] Polysaccharide based nanogels in the drug delivery system: Application as the carrier of pharmaceutical agents
Debele, Tilahun Ayane
Mekuria, Shewaye Lakew
Tsai, Hsieh-Chih
[J]. MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2016, 68 : 964 - 981
[10] Polysaccharides based nanomaterials for targeted anti-cancer drug delivery
Dheer, Divya
Arora, Divya
Jaglan, Sundeep
Rawal, Ravindra K.
Shankar, Ravi
[J]. JOURNAL OF DRUG TARGETING, 2017, 25 (01) : 1 - 16

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