A Catalytic Michael/Horner-Wadsworth-Emmons Cascade Reaction for Enantioselective Synthesis of Thiochromenes

被引：57
作者：
Choudhury, Abhijnan Ray [1 ]
Mukherjee, Santanu [1 ]
机构：
[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 10期
关键词：
asymmetric catalysis; bifunctional catalysis; cascade reactions; Horner-Wadsworth-Emmons reaction; sulfa-Michael addition; thiochromenes; ORGANOCATALYTIC ASYMMETRIC-SYNTHESIS; DYNAMIC KINETIC RESOLUTION; ALDOL REACTIONS; TANDEM; CONSTRUCTION; DERIVATIVES; CHROMENES; INHIBITOR; ALDEHYDES; ACCESS;
D O I：
10.1002/adsc.201300281
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A catalytic enantioselective sulfa-Michael/Horner-Wadsworth-Emmons reaction cascade has been developed, taking advantage of phosphonate as an electrophilic activator and a traceless binding site. Using a chiral bifunctional urea derivative as the catalyst, a variety of aryl and heteroaryl substituted thiochromenes was obtained in excellent yield with a high level of enantioselectivity.
引用
收藏
页码：1989 / 1995
页数：7
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