A Catalytic Michael/Horner-Wadsworth-Emmons Cascade Reaction for Enantioselective Synthesis of Thiochromenes

被引：57

作者：

Choudhury, Abhijnan Ray ^{[1
]}

Mukherjee, Santanu ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 10期

关键词：

asymmetric catalysis; bifunctional catalysis; cascade reactions; Horner-Wadsworth-Emmons reaction; sulfa-Michael addition; thiochromenes; ORGANOCATALYTIC ASYMMETRIC-SYNTHESIS; DYNAMIC KINETIC RESOLUTION; ALDOL REACTIONS; TANDEM; CONSTRUCTION; DERIVATIVES; CHROMENES; INHIBITOR; ALDEHYDES; ACCESS;

D O I：

10.1002/adsc.201300281

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A catalytic enantioselective sulfa-Michael/Horner-Wadsworth-Emmons reaction cascade has been developed, taking advantage of phosphonate as an electrophilic activator and a traceless binding site. Using a chiral bifunctional urea derivative as the catalyst, a variety of aryl and heteroaryl substituted thiochromenes was obtained in excellent yield with a high level of enantioselectivity.

引用

页码：1989 / 1995

页数：7

共 75 条

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