Postnatal exposure to low-dose bisphenol A influences various emotional conditions

被引:42
作者
Fujimoto, Tetsuya [1 ]
Kubo, Kazuhiko [2 ]
Nishikawa, Yasuo [1 ]
Aou, Shuji [3 ]
机构
[1] Osaka Dent Univ, Dept Physiol, Hirakata, Osaka 5731121, Japan
[2] Kyushu Univ, Grad Sch Med Sci, Dept Otorhinolaryngol, Fukuoka 8128582, Japan
[3] Kyushu Inst Technol, Deptartment Brain Sci & Engn, Wakamatsu Ku, Kitakyushu, Fukuoka 8080196, Japan
关键词
Bisphenol A; Postnatal exposure; Exploratory behavior; Depression-like behavior; Anxiety-like behavior; Breastfeeding; FORCED SWIMMING TEST; SEXUAL-DIFFERENTIATION; ANIMAL-MODEL; ENDOCRINE DISRUPTORS; ANTIDEPRESSANT DRUGS; BEHAVIORAL DESPAIR; NERVOUS-SYSTEM; MESSENGER-RNA; STRESS-ULCER; RAT-BRAIN;
D O I
10.2131/jts.38.539
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Bisphenol A (BPA) is one of the 'environmental endocrine disrupters' (EEDs) released by plastics and resin known to interfere with hormonal responses. In this study, female Wistar rats were exposed to low-dose BPA (24 mu g/kg/day) during 7 days after giving birth. The male and female offspring, exposed to the BPA through lactation, were evaluated using an open field test (OFT) at the age of six weeks, an elevated plus maze test (EPM) at seven weeks, and a forced swimming test (FST) at nine weeks. The OFT indicated that females were more active than males, and that BPA selectively increased rearing duration in males, thereby eliminating the gender effect. The results of EPM showed that BPA did not enhance the anxiety-like action; rather, it was associated with an anxiolytic-like action in females. In the FST, not only there was an increase in the immobility time, but also there was reduction of latency observed in BPA rats. It indicated that the depression-like responses were clearly enhanced by the postnatal exposure. Altogether, these data suggest that low-dose BPA ingested by neonates through breastfeeding may cause persistent aberrant behaviors that are relevant to emotions.
引用
收藏
页码:539 / 546
页数:8
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