Study of Dental Caries and PTH Gene

被引：1

作者：

Reis, Caio Luiz Bitencourt ^{[1
]}

Barbosa, Mariane Carolina Faria ^{[2
]}

de Lima, Daniela Coelho ^{[3
]}

Madalena, Isabela Ribeiro ^{[1
,4
,5
]}

Baratto-Filho, Flares ^{[4
]}

Proff, Peter ^{[6
]}

de Oliveira, Daniela Silva Barroso ^{[3
]}

Paddenberg, Eva ^{[6
]}

Kuechler, Erika Calvano ^{[6
]}

Kirschneck, Christian ^{[6
]}

机构：

[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Pediat Dent, Sao Paulo, Brazil

[2] Univ Fed Minas Gerais, Sch Dent, Dept Child & Adolescent Hlth, Belo Horizonte, Brazil

[3] Univ Fed Alfenas, Sch Dent, Dept Clin & Surg, Alfenas, Brazil

[4] Univ Regiao Joinville, Dept Dent, Joinville, Brazil

[5] Univ Fed Juiz de Fora, Dept Restorat Dent, Belo Horizonte, Brazil

[6] Univ Regensburg, Dept Orthodont, Regensburg, Germany

来源：

FRONTIERS IN DENTAL MEDICINE | 2021年 / 2卷

关键词：

dental caries; parathyroid hormone; polymorphism; single nucleotid polymorphism; children; PARATHYROID-HORMONE GENE; EARLY-CHILDHOOD CARIES; VITAMIN-D; ASSOCIATION; POLYMORPHISMS; CELLS;

D O I：

10.3389/fdmed.2021.703549

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Parathyroid hormone (PTH) is essential for calcium and phosphate homeostasis in odontogenesis-related cells. Therefore, the present study aimed to investigate the association between single nucleotide polymorphisms in the gene encoding PTH, and dental caries in Brazilian children. Three hundred and fifty-three children (170 boys and 183 girls, age ranging from 8 to 11 years old) were included in this study. The International System for Detection and Assessment of Carious Lesions (ICDAS) was used for diagnosis of dental caries. Visible biofilm was also evaluated during the clinical examination. Genomic DNA was extracted from saliva for real-time PCR to evaluate the single nucleotide polymorphisms rs6256, rs307247 and rs694 in PTH gene. Dental caries was classified in ICDAS0 vs. ICDAS1-6 or ICDAS1-2 vs. ICDAS3-6. Chi-square test, binary logistic regression adjusted by biofilm and haplotype analyses were performed (p < 0.05). Biofilm was associated with dental caries (p < 0.05). There were no associations between dental caries and rs6256, rs307247, rs694 in none of the analyses performed (p > 0.05). In conclusion, the present study supports that the single nucleotide polymorphisms rs6256, rs307247, and rs694 in the PTH-encoding gene are not associated with dental caries in Brazilian children.

引用

页数：6

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