Seizure-associated hippocampal volume loss: A longitudinal magnetic resonance study of temporal lobe epilepsy

被引：145

作者：

Briellmann, RS ^{[1
]}

Berkovic, SF ^{[1
]}

Syngeniotis, A ^{[1
]}

King, MA ^{[1
]}

Jackson, GD ^{[1
]}

机构：

[1] Univ Melbourne, Inst Brain Res, Austin & Repatriat Med Ctr, Dept Neurol, Heidelberg, Vic 3084, Australia

来源：

ANNALS OF NEUROLOGY | 2002年 / 51卷 / 05期

关键词：

D O I：

10.1002/ana.10171

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This longitudinal quantitative magnetic resonance imaging study of 24 patients with mild temporal lobe epilepsy shows an ipsilateral hippocampal volume decrease of 9% (range, -30 to +0.5%; p = 0.002, paired t test) over a period of 3.5 +/- 0.7 years. The hippocampal volume loss was correlated to the number of generalized seizures between the scans (P = 0.0007, r = 0.6), suggesting seizure-associated hippocampal damage.

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页码：641 / 644

页数：4

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