Probing the reactivity of o-phthalaldehydic acid/methyl ester: synthesis of N-isoindolinones and 3-arylaminophthalides

被引：33

作者：

Mamidyala, Sreeman K. ^{[1
]}

Cooper, Matthew A. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 75期

基金：

英国医学研究理事会;

关键词：

EFFICIENT SYNTHESIS; PRIMARY AMINES; ISOINDOLIN-1-ONES; ACID; ANALOGS;

D O I：

10.1039/c3cc43838d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new method for the synthesis of N-substituted isoindolinones and 3-arylaminophthalides was developed through aza-Wittig/cyclisation. The reaction of o-phthalaldehydic acid methyl ester with benzylic, aromatic and aliphatic azides gave N-isoindolinones whereas reaction of o-phthalaldehydic acid with the aromatic azides gave 3-arylaminophthalides.

引用

页码：8407 / 8409

页数：3

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