HELICOBACTER PYLORI HP0175 PROMOTES THE PRODUCTION OF IL-23, IL-6, IL-1β AND TGF-β

被引：2
作者：
Amedei, A. [1 ,2 ]
Munari, F. [3 ]
Della Bella, C. [1 ,2 ]
Niccolai, E. [1 ,2 ]
Benagiano, M. [1 ,2 ]
Bencini, L. [4 ]
Cianchi, F. [5 ]
Silvestri, E. [1 ,2 ]
D'Elios, S. [1 ]
Farsi, M. [4 ]
Prisco, D. [1 ,2 ]
Zanotti, G. [3 ]
De Bernard, M. [3 ]
Kundu, M. [6 ]
D'Elios, M. M. [1 ,2 ]
机构：
[1] Univ Florence, Dept Expt & Clin Med, I-50134 Florence, Italy
[2] Inst Med Pathol, Dept Biomed, Florence, Italy
[3] Univ Padua, Venetian Inst Mol Med, Padua, Italy
[4] Univ Florence, Dept Gen & Oncol Surg, I-50134 Florence, Italy
[5] Univ Florence, Dept Surg, I-50134 Florence, Italy
[6] Bose Inst, Dept Chem, Kolkata, India
来源：
EUROPEAN JOURNAL OF INFLAMMATION | 2013年 / 11卷 / 01期
关键词：
Helicobacter pylori; cytokines; IL-23; IL-1b; IL-6; TGF-b; UP-REGULATION; PROTEIN; CELLS; INFLAMMATION; ACTIVATION; ANTITUMOR; MUCOSA; RISK;
D O I：
10.1177/1721727X1301100127
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Helicobacter pylori infection induces a chronic gastric inflammatory infiltrate. This study was undertaken to evaluate the type of the innate immune responses elicited by the secreted peptidyl-prolyl cis-trans isomerase of H. pylon (100175). The cytokine production induced by HP0175 in neutrophils, and monocytes was evaluated. HP0175 was able to induce the expression of IL-23 in neutrophils, and monocytes, and IL-6, IL-1beta and TGF-beta in monocytes. These findings indicate that HP0175 is able to promote the activation of innate cells and the production of a cytokine milieu that may favour the development of Th17 response.
引用
收藏
页码：261 / 268
页数：8
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