The Complexity of Arterial Classical Monocyte Recruitment

被引：13
作者：
Drechsler, Maik [1 ]
Soehnlein, Oliver [1 ,2 ]
机构：
[1] Univ Munich, Inst Cardiovasc Prevent, DE-80336 Munich, Germany
[2] Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands
来源：
JOURNAL OF INNATE IMMUNITY | 2013年 / 5卷 / 04期
关键词：
Monocyte; Neutrophil; Platelet; Recruitment; Atherosclerosis; PREDICT CARDIOVASCULAR EVENTS; ATHEROSCLEROSIS-PRONE MICE; CELL-ADHESION MOLECULE-1; P-SELECTIN; LEUKOCYTE RECRUITMENT; HEMATOPOIETIC STEM; ENDOTHELIAL-CELLS; MACROPHAGE HETEROGENEITY; FUNCTIONAL INTERACTIONS; INFLAMMATORY MONOCYTES;
D O I：
10.1159/000348795
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Accumulation of classical monocytes is imperative for the progression of atherosclerosis. Hence, therapeutic interference with mechanisms of lesional monocyte recruitment, the primary mechanism controlling macrophage accumulation, may allow for targeting atheroprogression and its clinical complications. Here, we review the important role of classical monocytes in atheroprogression as well as their routes of arterial recruitment. We specifically highlight the role of cell adhesion molecules as well as of platelet-derived chemokines and neutrophil-borne alarmins. Copyright (C) 2013 S. Karger AG, Basel
引用
收藏
页码：358 / 366
页数：9
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