A new hydroxyapatite-based biocomposite for bone replacement

被引:59
作者
Bellucci, Devis [1 ]
Sola, Antonella [1 ]
Gazzarri, Matteo [2 ,3 ]
Chiellini, Federica [2 ,3 ]
Cannillo, Valeria [1 ]
机构
[1] Univ Modena & Reggio Emilia, Dept Engn Enzo Ferrari, I-41125 Modena, Italy
[2] Univ Pisa, Lab Bioact Polymer Mat Biomed & Environm Applicat, Pisa, Italy
[3] Univ Pisa, Dept Chem & Ind Chem, UdR INSTM, Pisa, Italy
来源
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2013年 / 33卷 / 03期
关键词
Composites; Glass-ceramics; Hydroxyapatite; Bioceramics; Bone tissue engineering; GLASS-REINFORCED HYDROXYAPATITE; ENHANCED MECHANICAL-PROPERTIES; BIOACTIVE GLASS; BIODEGRADATION BEHAVIOR; CERAMIC SCAFFOLDS; PHOSPHATE; 45S5; EXPRESSION; CRYSTALLIZATION; PROLIFERATION;
D O I
10.1016/j.msec.2012.11.038
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Since the 1970s, various types of ceramic, glass and glass-ceramic materials have been proposed and used to replace damaged bone in many clinical applications. Among them, hydroxyapatite (HA) has been successfully employed thanks to its excellent biocompatibility. On the other hand, the bioactivity of HA and its reactivity with bone can be improved through the addition of proper amounts of bioactive glasses, thus obtaining HA-based composites. Unfortunately, high temperature treatments (1200 degrees C divided by 1300 degrees C) are usually required in order to sinter these systems, causing the bioactive glass to crystallize into a glass-ceramic and hence inhibiting the bioactivity of the resulting composite. In the present study novel HA-based composites are realized and discussed. The samples can be sintered at a relatively low temperature (800 degrees C), thanks to the employment of a new glass (BG_Ca) with a reduced tendency to crystallize compared to the widely used 45S5 Bioglass (R). The rich glassy phase, which can be preserved during the thermal treatment, has excellent effects in terms of in vitro bioactivity; moreover, compared to composites based on 45S5 Bioglass (R) having the same HA/glass proportions, the samples based on BG_Ca displayed an earlier response in terms of cell proliferation. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:1091 / 1101
页数:11
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