IL-17A is a central regulator of lung tumor growth

被引：17

作者：

Reppert, Sarah ^{[1
]}

Koch, Sonja ^{[1
]}

Finotto, Susetta ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Inst Mol Pneumol, Labs Cellular & Mol Lung Immunol, Erlangen, Germany

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 05期

关键词：

IL-17A; tumor; lung; T-bet; T-regulatory cells; T-BET; CANCER; INTERLEUKIN-17; CELLS;

D O I：

10.4161/onci.19735

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In a recent study we reported increased expression of IL-17A in the lung of patients with lung adenocarcinoma. Local blockade of IL-17A in the lung, in a model of lung cancer revealed enhanced anti-tumor immunity characterized by increased IFN gamma, a diminished T-regulatory cell number and reduced tumor growth.

引用

页码：783 / 785

页数：3

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