Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy

被引：108

作者：

Vaidya, B

Imrie, H

Perros, P

Dickinson, J

McCarthy, MI

Kendall-Taylor, P

Pearce, SHS ^{[1
]}

机构：

[1] Univ Newcastle Upon Tyne, Sch Clin Med Sci, Dept Endocrinol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[2] Freeman Rd Hosp, Endocrine Unit, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England

[3] Royal Victoria Infirm, Dept Ophthalmol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[4] St Marys Hosp, Imperial Coll, Sch Med, Div Med,Sect Endocrinol, London W2 1PG, England

来源：

LANCET | 1999年 / 354卷 / 9180期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0140-6736(99)01465-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Smoking and demographic variables are known to be risk factors for the development of thyroid-associated orbitopathy (TAO) among patients with Graves' hyperthyroidism, but a firm genetic basis for TAO has not been established. We show that the presence and severity of TAO are associated with an allele of the cytotoxic T lymphocyte antigen-4-gene.

引用

页码：743 / 744

页数：2

共 5 条

[1]

BAHN RS, 1993, NEW ENGL J MED, V329, P1468

[2] AGE AND GENDER INFLUENCE THE SEVERITY OF THYROID-ASSOCIATED OPHTHALMOPATHY - A STUDY OF 101 PATIENTS ATTENDING A COMBINED THYROID EYE CLINIC [J].