CLINICAL ASSESSMENT OF THE 1/3 RADIUS USING A NEW DESKTOP ULTRASONIC BONE DENSITOMETER

被引:18
作者
Stein, Emily M. [1 ]
Rosete, Fernando [1 ]
Young, Polly [1 ]
Kamanda-Kosseh, Mafo [1 ]
McMahon, Donald J. [1 ]
Luo, Gangming [2 ,3 ]
Kaufman, Jonathan J. [2 ,4 ]
Shane, Elizabeth [1 ]
Siffert, Robert S. [4 ]
机构
[1] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA
[2] CyberLogic Inc, New York, NY 10012 USA
[3] NYU, Sch Med, Dept Rehabil Med, New York, NY USA
[4] Mt Sinai Sch Med, Dept Orthoped, New York, NY USA
基金
美国国家卫生研究院;
关键词
Osteoporosis; Bone mineral density; Ultrasound; Net time delay; DXA; Radius; QUANTITATIVE ULTRASOUND; CANCELLOUS BONE; IN-VITRO; OSTEOPOROSIS; FRACTURES; STRENGTH; DENSITY; DISCRIMINATION; SIMULATION; DIAGNOSIS;
D O I
10.1016/j.ultrasmedbio.2012.09.024
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
The objectives of this study were to evaluate the capability of a novel ultrasound device to clinically estimate bone mineral density (BMD) at the 1/3 radius. The device rests on a desktop and is portable, and permits real-time evaluation of the radial BMD. The device measures two net time delay (NTD) parameters, NTDDW and NTDCW. NTDDW is defined as the difference between the transit time of an ultrasound pulse to travel through soft-tissue, cortex and medullary cavity, and the transit time through soft tissue only of equal overall distance. NTDCW is defined as the difference between the transit time of an ultrasound pulse to travel through soft-tissue and cortex only, and the transit time through soft tissue only again of equal overall distance. The square root of the product of these two parameters is a measure of the radial BMD at the 1/3 location as measured by dual-energy X-ray absorptiometry (DXA). A clinical IRB-approved study measured ultrasonically 60 adults at the 1/3 radius. BMD was also measured at the same anatomic site and time using DXA. A linear regression using NTD produced a linear correlation coefficient of 0.93 (p < 0.001). These results are consistent with previously reported simulation and in vitro studies. In conclusion, although X-ray methods are effective in bone mass assessment, osteoporosis remains one of the largest undiagnosed and under-diagnosed diseases in the world today. The research described here should enable significant expansion of diagnosis and monitoring of osteoporosis through a desktop device that ultrasonically assesses bone mass at the 1/3 radius. (E-mail: jjkaufman@cyberlogic.org) (C) 2013 World Federation for Ultrasound in Medicine & Biology.
引用
收藏
页码:388 / 395
页数:8
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