Synthesis and characterization of some novel fatty acid analogues: A preliminary investigation on their activity against human lung carcinoma cell line

被引：13

作者：

Jubie, Selvaraj ^{[1
]}

Dhanabal, Palanisamy ^{[2
]}

Azam, Mohammed Afzal ^{[1
]}

Muruganantham, Nithyanantham ^{[2
]}

Kalirajan, Rajagopal ^{[1
]}

Elango, Kannan ^{[2
]}

机构：

[1] JSS Coll Pharm, Dept Pharmaceut Chem, Ooty 643001, Tamil Nadu, India

[2] JSS Coll Pharm, Dept Phytopharm & Phytomed, Udhagamandalam, Tamil Nadu, India

来源：

LIPIDS IN HEALTH AND DISEASE | 2013年 / 12卷

关键词：

Spirulina platensis; Stearic acid; Gamma linolenic acid; Cytotoxicity; DERIVATIVES;

D O I：

10.1186/1476-511X-12-45

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Preparation of some novel heterocyclic compounds with long alkyl and alkenyl chain of cytotoxic activity. Methods: Gamma linolenic acid, a poly unsaturated fatty acid and stearic acid, a saturated fatty acid were isolated from the microalga Spirulina platensis. Some novel gamma linolenic acid and stearic acid analogues having 1,3, 4-oxadiazole and 1,2,4-triazole were synthesized and characterized by IR, H-1 NMR, C-13 NMR and mass spectral analysis. Cytotoxicity of these compounds was evaluated by the growth inhibition of A-549 cells in-vitro. Results: Compound 1 and 3 showed comparable cytotoxicity against the human lung carcinoma A-549 cell lines.

引用

页数：5

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