Phenyl boronic acid-modified lipid nanocarriers of niclosamide for targeting triple-negative breast cancer

被引：27
|
作者：
Pindiprolu, Sai Kiran S. S. [1 ]
Krishnamurthy, Praveen T. [1 ]
Ghanta, Venkata Rao [2 ]
Chintamaneni, Pavan Kumar [1 ]
机构：
[1] JSS Acad Higher Educ & Res, JSS Coll Pharm, Dept Pharmacol, The Nilgiris 643001, Tamil Nadu, India
[2] GVK Biosci Private Ltd, IDA Nacharam, Synthet Organ Chem Div, Hyderabad 500076, Telangana, India
来源：
NANOMEDICINE | 2020年 / 15卷 / 16期
关键词：
metastasis; niclosamide; STAT3; triple-negative breast cancer; tumor relapse; STEM-CELLS; DRUG-DELIVERY; MESENCHYMAL TRANSITION; DIALLYL DISULFIDE; NANOPARTICLES; STAT3; GROWTH; FORMULATION; CONJUGATE; DESIGN;
D O I：
10.2217/nnm-2020-0003
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: To study the active targeting efficacy of phenylboronic acid-modified niclosamide solid lipid nanoparticles (PBA-Niclo-SLN) in triple-negative breast cancer (TNBC). Materials & methods: PBA-Niclo-SLNs were formulated by an emulsification-solvent evaporation method using PBA-associated stearylamine (PBSA) as lipid. The drug uptake and the anticancer propensity of PBA-Niclo-SLN were studied in TNBC (MDA-MB231) cells and tumor-bearing mice. Results: PBA-Niclo-SLN formulation resulted in greater antitumor efficacy by inducing G0/G1 cell cycle arrest and apoptosis. Besides, PBA-Niclo-SLN effectively inhibited STAT3, CD44(+)/CD24(-) TNBC stem cell subpopulation, epithelial-mesenchymal transition markers. Besides, PBA-Niclo-SLN selectively accumulated at the tumor site with more significant tumor regression and improved the survivability in TNBC tumor-bearing mice. Conclusion: PBA-Niclo-SLN formulation would be an effective strategy to eradicate TNBC cells (breast cancer stem cells and nonbreast cancer stem cells) efficiently. Graphical abstract
引用
收藏
页码：1551 / 1565
页数：15
相关论文
共 50 条
  • [21] The efficacy of betulinic acid in triple-negative breast cancer
    Weber, Daniel
    Zhang, Mixia
    Zhuang, Pengwei
    Zhang, Yanjun
    Wheat, Janelle
    Currie, Geoffrey
    Al-Eisawi, Zaynab
    SAGE OPEN MEDICINE, 2014, 2
  • [22] Triple-Negative Breast Cancer
    Winkeljohn, Debra L.
    CLINICAL JOURNAL OF ONCOLOGY NURSING, 2008, 12 (06) : 861 - 863
  • [23] Triple-Negative Breast Cancer
    Hudis, Clifford A.
    CANCER JOURNAL, 2010, 16 (01): : 10 - 11
  • [24] Triple-Negative Breast Cancer
    Quyen D. Chu
    King, Tari
    Hurd, Thelma
    INTERNATIONAL JOURNAL OF BREAST CANCER, 2012, 2012
  • [25] Triple-negative breast cancer
    Chacon, Reinaldo D.
    Costanzo, Maria V.
    BREAST CANCER RESEARCH, 2010, 12
  • [26] Triple-negative breast cancer
    Stockmans, Gert
    Deraedt, Karen
    Wildiers, Hans
    Moerman, Philippe
    Paridaens, Robert
    CURRENT OPINION IN ONCOLOGY, 2008, 20 (06) : 614 - 620
  • [27] Triple-Negative Breast Cancer
    Foulkes, William D.
    Smith, Ian E.
    Reis-Filho, Jorge S.
    NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (20): : 1938 - 1948
  • [28] Triple-negative breast cancer
    Bartsch R.
    Ziebermayr R.
    Zielinski C.C.
    Steger G.G.
    Wiener Medizinische Wochenschrift, 2010, 160 (7-8) : 174 - 181
  • [29] Triple-Negative Breast Cancer
    Liedtke, Cornelia
    Schmutzler, Rita
    Schneeweiss, Andreas
    Loibl, Sybille
    Thill, Marc
    Heitz, Florian
    BREAST CARE, 2010, 5 (05) : 359 - 363
  • [30] Triple-negative breast cancer
    Aschenbrenner, Diane S.
    AMERICAN JOURNAL OF NURSING, 2020, 120 (08) : 22 - 23
12345