Raman-on-chip device and detection fibres with fibre Bragg grating for analysis of solutions and particles

被引：32

作者：

Dochow, Sebastian ^{[1
]}

Becker, Martin ^{[1
]}

Spittel, Ron ^{[1
]}

Beleites, Claudia ^{[1
]}

Stanca, Sarmiza ^{[1
]}

Latka, Ines ^{[1
]}

Schuster, Kay ^{[1
]}

Kobelke, Jens ^{[1
]}

Unger, Sonja ^{[1
]}

Henkel, Thomas ^{[1
]}

Mayer, Guenter ^{[1
]}

Albert, Jens ^{[1
]}

Rothhardt, Manfred ^{[1
]}

Krafft, Christoph ^{[1
]}

Popp, Juergen ^{[1
,2
,3
]}

机构：

[1] Inst Photon Technol IPHT, D-07745 Jena, Germany

[2] Univ Jena, Inst Phys Chem, D-07743 Jena, Germany

[3] Univ Jena, Abbe Ctr Photon, D-07743 Jena, Germany

来源：

LAB ON A CHIP | 2013年 / 13卷 / 06期

关键词：

CELLS; MICROSPECTROSCOPY; SPECTROSCOPY;

D O I：

10.1039/c2lc41169e

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An all-fibre based Raman-on-chip setup is introduced which enables analysis of solutions and trapped particles without microscopes or objectives. Beside the novel quartz microfluidic chip, innovative multi-core single-mode fibres with integrated fibre Bragg gratings are used for detection. The limit of quantitation is 7.5 mM for urea and 2.5 mM for nicotine with linear Raman spectroscopy. This is an improvement of more than two orders of magnitude compared with previous fibre-based microfluidic Raman detection schemes. Furthermore, our device was combined with optical traps to collect Raman-on-chip spectra of spherical polymer beads.

引用

页码：1109 / 1113

页数：5

共 20 条

[1] Fiber probe based microfluidic raman spectroscopy [J].