An SDF-1 trap for myeloid cells stimulates angiogenesis

被引：56

作者：

de Almodovar, CR ^{[1
]}

Luttun, A ^{[1
]}

Carmeliet, P ^{[1
]}

机构：

[1] Katholieke Univ Leuven VIB, Ctr Transgene Technol & Gene Therapy, B-3000 Louvain, Belgium

来源：

CELL | 2006年 / 124卷 / 01期

关键词：

D O I：

10.1016/j.cell.2005.12.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this issue of Cell, Grunewald et al. (2006) examine the role of hematopoietic cells in the formation of new blood vessels. They show that organ-specific expression of vascular endothelial growth factor (VEGF) is sufficient to mobilize and recruit hematopoietic cells from the bone marrow to the blood, but retention of the proangiogenic subpopulation of hematopoietic cells in peripheral organs requires an additional factor, stromal-derived factor 1 (SDF-1).

引用

页码：18 / 21

页数：4

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