New sequence variants associated with bone mineral density

被引：272

作者：

Styrkarsdottir, Unnur ^{[1
,2
]}

Halldorsson, Bjarni V. ^{[1
]}

Gretarsdottir, Solveig ^{[1
]}

Gudbjartsson, Daniel F. ^{[1
]}

Walters, G. Bragi ^{[1
]}

Ingvarsson, Thorvaldur ^{[3
]}

Jonsdottir, Thorbjorg ^{[1
]}

Saemundsdottir, Jona ^{[1
]}

Snorradottir, Steinunn ^{[1
]}

Center, Jacqueline R. ^{[4
,5
,6
]}

Nguyen, Tuan V. ^{[4
,5
,6
]}

Alexandersen, Peter ^{[7
]}

Gulcher, Jeffrey R. ^{[1
]}

Eisman, John A. ^{[4
,5
,6
]}

Christiansen, Claus ^{[8
]}

Sigurdsson, Gunnar ^{[9
]}

Kong, Augustine ^{[1
]}

Thorsteinsdottir, Unnur ^{[1
]}

Stefansson, Kari ^{[1
]}

机构：

[1] deCODE Genet, IS-101 Reykjavik, Iceland

[2] Reykjavik Univ, IS-103 Reykjavik, Iceland

[3] Univ Akureyri, Inst Hlth Sci, FSA Univ Hosp, IS-600 Akureyri, Iceland

[4] St Vincents Hosp, Garvan Inst Med Res, Darlinghurst, NSW 2010, Australia

[5] St Vincents Hosp, Sydney, NSW 2010, Australia

[6] Univ New S Wales, Sydney, NSW 2010, Australia

[7] Ctr Clin & Basic Res AS, DK-2750 Ballerup, Denmark

[8] Nordic Biosci AS, DK-2730 Herlev, Denmark

[9] Univ Iceland, Landspitali Univ Hosp, Div Endocrinol & Metab, IS-108 Reykjavik, Iceland

来源：

NATURE GENETICS | 2009年 / 41卷 / 01期

关键词：

OSTEOPOROTIC FRACTURES; BUCHEM-DISEASE; SOST GENE; BMD; SCLEROSTEOSIS; PROTEIN; LRP5; HIP;

D O I：

10.1038/ng.284

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.

引用

页码：15 / 17

页数：3

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