Comprehensive Analysis of the Association between Human Diseases and Water Pollutants

被引:16
作者
Jiang, Xinlu [1 ]
Zhang, Huanhuan [2 ]
Wang, Xiaoyan [1 ]
Zhang, Xu [3 ]
Ding, Kaiyang [1 ]
机构
[1] Anhui Med Univ, Anhui Prov Hosp, Dept Hematol, Hefei 230032, Peoples R China
[2] Wannan Med Coll, Dept Resp, Wuhu 241002, Peoples R China
[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Urol, Nanjing 210029, Peoples R China
关键词
water pollutants; diseases; phenotypes and pathways; toxicogenomic analysis; TOXICOLOGY; POLLUTION;
D O I
10.3390/ijerph192416475
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Drinking water is an important natural resource. For many people worldwide, especially in developing countries, access to safe drinking water is still a dream. An increasing number of human activities and industrialization have caused various physical, chemical, and biological pollutants to enter water bodies, affecting human health. Water pollutants contain a vast number of additives, such as perfluorinated chemicals, polybrominated diphenyl ethers, phthalate, nanomaterials, insecticides, microcystins, heavy metals, and pharmacologies. In this work, we aim to explore the potential relationship between water pollutants and human diseases. Here, we explored an integrative approach to identify genes, biological processes, molecular functions, and diseases linked to exposure to these water pollutants. These processes and functions affected by water pollutants are related to many diseases, including colonic neoplasms, breast neoplasms, hepatitis B, bladder cancer, and human cytomegalovirus infection. In addition, further analysis revealed the genes that play a key role in the human diseases induced by water pollutants. Therefore, conducting an integrative toxicogenomic analysis of water pollutants is more appropriate for evaluating the potential effects of water pollutants on human health.
引用
收藏
页数:13
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