Ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

被引：5

作者：

Mohideen, M. Nizam ^{[1
]}

Pandi, A. Subbiah ^{[2
]}

Rasheeth, A. ^{[3
]}

Huq, C. A. M. A. ^{[3
]}

Nizar, S. Syed ^{[3
]}

机构：

[1] New Coll Autonomous, Dept Phys, Madras 600014, Tamil Nadu, India

[2] Presidency Coll Autonomous, Dept Phys, Madras 600005, Tamil Nadu, India

[3] New Coll Autonomous, Dept Chem, Madras 600014, Tamil Nadu, India

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2008年 / 64卷

关键词：

D O I：

10.1107/S1600536808025610

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

The title compound, C14H16N2O3, belongs to a group of esters of 2-oxo- and 1,2,3,4-tetrahydropyrimidine-5-carboxylic acids, which exhibit a wide spectrum of biological activities. The dihydropyrimidine ring adopts a screw-boat conformation. The crystal packing is stabilized by strong N - H center dot center dot center dot O and weak C - H center dot center dot center dot O intermolecular hydrogen bonds. An intramolecular C - H center dot center dot center dot O hydrogen bond is also present.

引用

页码：O1752 / U1888

页数：9

共 11 条

[1] DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS .3. 3-CARBAMOYL-4-ARYL-1,2,3,4-TETRAHYDRO-6-METHYL-5-PYRIMIDINECARBOXYLIC ACID-ESTERS AS ORALLY EFFECTIVE ANTIHYPERTENSIVE AGENTS [J].

ATWAL, KS ;

SWANSON, BN ;

UNGER, SE ;

FLOYD, DM ;

MORELAND, S ;

HEDBERG, A ;

OREILLY, BC .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (02) :806-811

[2] ANTIALLERGIC ACTIVITY OF 2-PHENYL-8-AZAPURIN-6-ONES [J].

BROUGHTON, BJ ;

CHAPLEN, P ;

KNOWLES, P ;

LUNT, E ;

MARSHALL, SM ;

PAIN, DL ;

WOOLDRIDGE, KRH .

JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (11) :1117-1122

[3]

Bruker, 2004, APEX2 SAINT

[4] GENERAL DEFINITION OF RING PUCKERING COORDINATES [J].

CREMER, D ;

POPLE, JA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (06) :1354-1358

[5]

Farrugia L.J., 1997, J APPL CRYSTALLOGR, V30, P565

[6]

Kappe CO, 1997, TETRAHEDRON, V53, P2803

[7] Ethyl 4-(4-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate [J].

Li, M ;

Guo, WS ;

Wen, LR ;

Qi, WY .

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2005, 61 :O531-O533

[8] RING ASYMMETRY PARAMETERS FROM OUT-OF-PLANE ATOMIC DISPLACEMENTS [J].

NARDELLI, M .

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1983, 39 (AUG) :1141-1142

[9] ENANTIOSELECTIVE TOTAL SYNTHESIS OF (-)-PTILOMYCALIN-A [J].

OVERMAN, LE ;

RABINOWITZ, MH ;

RENHOWE, PA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (09) :2657-2658

[10] A short history of SHELX [J].

Sheldrick, George M. .

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2008, 64 :112-122

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