Anxiety correlates to decreased blood and prefrontal cortex IGF-1 levels in streptozotocin induced diabetes

被引：64

作者：

Aksu, Ilkay ^{[1
]}

Ates, Mehmet ^{[2
]}

Baykara, Basak ^{[3
]}

Kiray, Muge ^{[1
]}

Sisman, Ali Riza ^{[4
]}

Buyuk, Erkan ^{[5
]}

Baykara, Burak ^{[6
]}

Cetinkaya, Caner ^{[1
]}

Gumus, Hikmet ^{[1
]}

Uysal, Nazan ^{[1
]}

机构：

[1] Dokuz Eylul Univ, Fac Med, Dept Physiol, TR-35210 Alsancak, Turkey

[2] Dokuz Eylul Univ, High Sch Phys Therapy & Rehabil Histol & Embryol, TR-35210 Alsancak, Turkey

[3] Dokuz Eylul Univ, Fac Med, Vocat Sch Hlth Serv, TR-35210 Alsancak, Turkey

[4] Dokuz Eylul Univ, Fac Med, Dept Biochem, Izmir, Turkey

[5] Montefiore Med Ctr, Albert Einstein Coll Med, Div Reprod Endocrinol & Infertil, Dept Obstet Gynecol & Womens Hlth, Bronx, NY 10467 USA

[6] Dokuz Eylul Univ, Fac Med, Dept Child & Adolescent Psychiat, Izmir, Turkey

来源：

NEUROSCIENCE LETTERS | 2012年 / 531卷 / 02期

关键词：

Diabetes; Anxiety; IGF-1; SOD; MDA; Corticosterone; Prefrontal cortex; TRAUMATIC BRAIN-INJURY; OXIDATIVE STRESS; GENE-EXPRESSION; PITUITARY; RECEPTOR; RATS; MICE; AXIS; RESPONSIVENESS; INVOLVEMENT;

D O I：

10.1016/j.neulet.2012.10.045

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It is well known that diabetes mellitus may cause neuropsychiatric disorders such as anxiety disorders. Diabetes may also cause reduced IGF-1 (insulin like growth factor-1) levels in brain and blood. The purpose of the present study was to investigate the relationship between diabetes induced anxiety and IGF-1 levels in diabetic rats. The anxiety levels of rats were assessed 2 weeks after intraperitoneal injection of streptozotocin. Diabetic rats had higher levels of anxiety, as they spent more time in closed branches in elevated-plus-maze-test and less time in the center cells of open-field-arena. Prefrontal cortex (PFC) IGF-1 levels and neuron numbers were decreased and apoptosis was increased in diabetic rats. Blood IGF-1 levels decreased in a time dependent fashion following streptozotocin injection while blood corticosterone levels increased. They had higher malondialdehyde levels and lower superoxide dismutase enzyme activity. Oxidative stress may negatively affect blood and PFC tissue IGF-1 levels. Reduction in IGF-1 may cause PFC damage, which may eventually trigger anxiety in diabetic rats. Therapeutic strategies that increase blood and brain tissue IGF-1 levels may be promising to prevent psychiatric sequelae of diabetes mellitus. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：176 / 181

页数：6

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