Complementary analysis of microRNA and mRNA expression during phorbol 12-myristate 13-acetate (TPA)-induced differentiation of HL-60 cells

被引：41
作者：
Chen, Ailiang [1 ,2 ,3 ]
Luo, Mingyong [3 ]
Yuan, Guohua [4 ]
Yu, Jian [1 ,2 ,3 ]
Deng, Tuo [1 ,2 ,3 ]
Zhang, Liang [3 ]
Zhou, Yuxiang [1 ,2 ,3 ]
Mitchelson, Keith [1 ,3 ]
Cheng, Jing [1 ,2 ,3 ]
机构：
[1] Tsinghua Univ, Sch Med, Med Syst Biol Res Ctr, Beijing 100084, Peoples R China
[2] Tsinghua Univ, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China
[3] Beijing Biochip Technol & CapitalBio Corp, Natl Engn Res Ctr, Beijing 102206, Peoples R China
[4] Affiliated Hosp N Sichuan Med Coll, Inst Rheumatol & Immunol, Nanchong 637000, Sichuan, Peoples R China
来源：
BIOTECHNOLOGY LETTERS | 2008年 / 30卷 / 12期
关键词：
Cell differentiation; HL-60; Microarray; MicroRNA; TPA;
D O I：
10.1007/s10529-008-9800-8
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
MicroRNAs (miRNAs) and mRNAs constitute an important part of gene regulatory networks, influencing diverse biological phenomena. To discover novel regulatory pathways during myeloid differentiation, we performed miRNA as well as mRNA expression profiling of in vitro-differentiating HL-60 cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA). The main findings were up-regulation of miR-146a/b, miR-21, miR-221, miR-222, miR-155, miR-26a and down-regulation of miR-199a*, miR-181c, miR-142-3p, miR-92. After integrating the miRNA and mRNA expression data into a Transcriptome Interaction Database by Molecule Annotation System (MAS) software, a number of differently expressed mRNAs were revealed as potential targets of these miRNAs.
引用
收藏
页码：2045 / 2052
页数：8
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