Fasting apolipoprotein B48 is associated with asymptomatic peripheral arterial disease in type 2 diabetic subjects: A case-control study

被引：10

作者：

Lapice, Emanuela ^{[1
]}

Cipriano, Paola ^{[1
]}

Patti, Lidia ^{[1
]}

Romano, Geremia ^{[2
]}

Vaccaro, Olga ^{[1
]}

Rivellese, Angela A. ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Clin & Expt Med, I-80131 Naples, Italy

[2] Univ Naples Federico II, Dept Clin & Expt Med, Asl Na NORD 2, I-80131 Naples, Italy

来源：

ATHEROSCLEROSIS | 2012年 / 223卷 / 02期

关键词：

Postprandial metabolism; Peripheral artery disease; Type; 2; diabetes; POSTPRANDIAL LIPEMIA; B-48;

D O I：

10.1016/j.atherosclerosis.2012.05.038

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To test whether there is an association between fasting ApoB48 level, a marker of the residual presence of intestinally derived TRLs lipoproteins, thought to be highly atherogenic, and peripheral artery disease (PAD) in type 2 diabetic patients independent of fasting plasma lipids. Methods: We studied 87 patients with type 2 diabetes: 34 with asymptomatic PAD (ankle/brachial index < 0.9) and 53 without PAD matched on age (+/- 2 years), gender and BMI (+/- 2 kg/m(2)). The plasma fasting ApoB48 was measured by ELISA. Results: Patients with PAD had significantly higher ApoB48 levels (1.529 +/- 1.253 vs 1.095 +/- 0.667 mu g/ml p = 0.04) than those without PAD independent of major confounders, such as duration of diabetes, smoking status, HbA1c, systolic blood pressure and fasting plasma lipids. Conclusions: Fasting ApoB48 was independently associated with asymptomatic PAD in patients with type 2 diabetes. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：504 / 506

页数：3

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