How to Diagnose and Phenotype Asthma

被引：33
作者：
Nair, Parameswaran
Dasgupta, Angira
Brightling, Christopher E. [1 ]
Chung, Kian Fan [2 ,3 ]
机构：
[1] Univ Leicester, Glenfield Hosp, Infect & Inflammat Inst, Leicester LE3 9QP, Leics, England
[2] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London 5W3 6NP, England
[3] Royal Brompton Hosp, NIHR Biomed Res Unit, London SW3 6NP, England
来源：
CLINICS IN CHEST MEDICINE | 2012年 / 33卷 / 03期
关键词：
Asthma; Phenotyping; Inflammation; EXHALED NITRIC-OXIDE; SPUTUM CELL COUNTS; AIRWAY WALL THICKNESS; RELATIVE CORTICOSTEROID INSENSITIVITY; BLOOD MONONUCLEAR-CELLS; PEAK EXPIRATORY FLOW; COMPUTED-TOMOGRAPHY; LUNG-FUNCTION; NEUTROPHILIC INFLAMMATION; BRONCHIAL HYPERRESPONSIVENESS;
D O I：
10.1016/j.ccm.2012.05.003
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Asthma has been described as a chronic disease of the airways characterized by variable airflow obstruction, airway hyperresponsiveness, and airway inflammation. This review discusses the diagnosis and phenotyping of asthma, with a special emphasis on phenotyping based on the nature of cellular inflammation and radiological imaging and how this could be used to direct the treatment of asthma and, in the future, to apply specifically directed therapies to specific phenotypes.
引用
收藏
页码：445 / +
页数：15
相关论文
共 110 条
[51]  
Hatipoglu Umur, 2004, Clin Mol Allergy, V2, P4
[52]   Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma [J].
Hew, Mark ;
Bhavsar, Pankaj ;
Torrego, Alfons ;
Meah, Sally ;
Khorasani, Nadia ;
Barnes, Peter J. ;
Adcock, Ian ;
Chung, Kian Fan .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006, 174 (02) :134-141
[53]   Tumour necrosis factor (TNFα) as a novel therapeutic target in symptomatic corticosteroid dependent asthma [J].
Howarth, PH ;
Babu, KS ;
Arshad, HS ;
Lau, L ;
Buckley, M ;
McConnell, W ;
Beckett, P ;
Al Ali, M ;
Chauhan, A ;
Wilson, SJ ;
Reynolds, A ;
Davies, DE ;
Holgate, ST .
THORAX, 2005, 60 (12) :1012-1018
[54]   Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment):: INNOVATE [J].
Humbert, M ;
Beasley, R ;
Ayres, J ;
Slavin, R ;
Hébert, J ;
Bousquet, J ;
Beeh, KM ;
Ramos, S ;
Canonica, GW ;
Hedgecock, S ;
Fox, H ;
Blogg, M ;
Surrey, K .
ALLERGY, 2005, 60 (03) :309-316
[55]   Exhaled breath condensate: An evolving tool for noninvasive evaluation of lung disease [J].
Hunt, J .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 110 (01) :28-34
[56]   Neutrophilic inflammation in severe persistent asthma [J].
Jatakanon, A ;
Uasuf, C ;
Maziak, W ;
Lim, S ;
Chung, KF ;
Barnes, PJ .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 160 (05) :1532-1539
[57]   Determining asthma treatment by monitoring sputum cell counts:: effect on exacerbations [J].
Jayaram, L ;
Pizzichini, MM ;
Cook, RJ ;
Boulet, LP ;
Lemière, C ;
Pizzichini, E ;
Cartier, A ;
Hussack, P ;
Goldsmith, CH ;
Laviolette, M ;
Parameswaran, K ;
Hargreave, FE .
EUROPEAN RESPIRATORY JOURNAL, 2006, 27 (03) :483-494
[58]   Obesity and childhood asthma - mechanisms and manifestations [J].
Jensen, Megan E. ;
Wood, Lisa G. ;
Gibson, Peter G. .
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 12 (02) :186-192
[59]  
Kelly MM, 2001, METH MOLEC MED, V56, P77, DOI 10.1385/1-59259-151-5:77
[60]   Bronchial neutrophilia in patients with noninfectious status asthmaticus [J].
Lamblin, C ;
Gosset, P ;
Tillie-Leblond, I ;
Saulnier, F ;
Marquette, CH ;
Wallaert, B ;
Tonnel, AB .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 157 (02) :394-402
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